@article{84dc660f877e4cbbb25e3d24decd3d86,
title = "Synthesis and antitumor activity of des-AB analogue of steroidal saponin OSW-1",
abstract = "Simplified des-AB-type aglycone of antitumor steroidal saponin OSW-1 was concisely prepared starting from readily available Hajos ketone. We further completed the synthesis of des-AB-OSW-1 analogue by the installation of the disaccharide moiety into the des-AB aglycone, and evaluated its antitumor activity. The results indicated that a truncated aglycone drug design strategy based on OSW-1 would be a promising approach for the development of novel antitumor agents.",
keywords = "Aglycone, Antitumor agents, Drug design, OSW-1, Organic synthesis",
author = "Daishiro Minato and Bozhi Li and Dejun Zhou and Yasumi Shigeta and Naoki Toyooka and Hiroaki Sakurai and Kenji Sugimoto and Hideo Nemoto and Yuji Matsuya",
note = "Funding Information: This work was supported in part by a Grant-in-Aid (no. 15390004 ) for Scientific Research by the Ministry of Education, Culture, Sports, Science, and Technology of the Japanese Government . ",
year = "2013",
month = sep,
day = "16",
doi = "10.1016/j.tet.2013.06.105",
language = "英語",
volume = "69",
pages = "8019--8024",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Ltd.",
number = "37",
}