Studies on the aconitine-type alkaloids in decoction of kampo prescriptions containing Aconiti Tuber

Masanori Taki*, Kaoru Nakajima, Hiroshi Sasaki, Yasuhiro Komatsu, Minoru Okada, Takashi Itoh, Kazuhiko Nagasaka, Toshiaki Kita, Naotoshi Shibahara, Katsutoshi Terasawa

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

2 被引用数 (Scopus)

抄録

When Aconiti Tuber (6g) was decocted with Corni Fructus (3g) in boiling water (800mL → 400mL), the total amount of the aconitine diester alkaloids in the decoction was 0.346mg and the pH value of the decoction was 5.1. When only Aconiti Tuber (6g) was decocted in citrate-hydrochloric acid buffer (pH4.0), the decoction contained 6.61mg of the alkaloids, and when it was decocted with water (pH7.8), the decoction contained 0.031mg of the alkaloids. The alkaloid content in a decoction prepared at pH4.0 was 200 times that in the decoction of pH7.8. These results suggest that the pH of decoction affects the hydrolysis reaction of the alkaloids in the decoction considerably.

本文言語英語
ページ(範囲)434-439
ページ数6
ジャーナルNatural Medicines
52
5
出版ステータス出版済み - 1998

ASJC Scopus 主題領域

  • 創薬
  • 補完代替医療
  • 薬科学
  • 有機化学

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