Studies on the aconitine-type alkaloids in decoction of kampo prescriptions containing Aconiti Tuber

Masanori Taki; Kaoru Nakajima; Hiroshi Sasaki; Yasuhiro Komatsu; Minoru Okada; Takashi Itoh; Kazuhiko Nagasaka; Toshiaki Kita; Naotoshi Shibahara; Katsutoshi Terasawa

Studies on the aconitine-type alkaloids in decoction of kampo prescriptions containing Aconiti Tuber

Masanori Taki^*, Kaoru Nakajima, Hiroshi Sasaki, Yasuhiro Komatsu, Minoru Okada, Takashi Itoh, Kazuhiko Nagasaka, Toshiaki Kita, Naotoshi Shibahara, Katsutoshi Terasawa

^*Corresponding author for this work

Kampo Education and Training Center, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

When Aconiti Tuber (6g) was decocted with Corni Fructus (3g) in boiling water (800mL → 400mL), the total amount of the aconitine diester alkaloids in the decoction was 0.346mg and the pH value of the decoction was 5.1. When only Aconiti Tuber (6g) was decocted in citrate-hydrochloric acid buffer (pH4.0), the decoction contained 6.61mg of the alkaloids, and when it was decocted with water (pH7.8), the decoction contained 0.031mg of the alkaloids. The alkaloid content in a decoction prepared at pH4.0 was 200 times that in the decoction of pH7.8. These results suggest that the pH of decoction affects the hydrolysis reaction of the alkaloids in the decoction considerably.

Original language	English
Pages (from-to)	434-439
Number of pages	6
Journal	Natural Medicines
Volume	52
Issue number	5
State	Published - 1998

Keywords

Aconiti Tuber
Aconitine-type alkaloids
Buffer solution
Corni Fructus
Decoction

ASJC Scopus subject areas

Drug Discovery
Complementary and alternative medicine
Pharmaceutical Science
Organic Chemistry

Cite this

@article{734d661debca48b787d086add6c50148,

title = "Studies on the aconitine-type alkaloids in decoction of kampo prescriptions containing Aconiti Tuber",

abstract = "When Aconiti Tuber (6g) was decocted with Corni Fructus (3g) in boiling water (800mL → 400mL), the total amount of the aconitine diester alkaloids in the decoction was 0.346mg and the pH value of the decoction was 5.1. When only Aconiti Tuber (6g) was decocted in citrate-hydrochloric acid buffer (pH4.0), the decoction contained 6.61mg of the alkaloids, and when it was decocted with water (pH7.8), the decoction contained 0.031mg of the alkaloids. The alkaloid content in a decoction prepared at pH4.0 was 200 times that in the decoction of pH7.8. These results suggest that the pH of decoction affects the hydrolysis reaction of the alkaloids in the decoction considerably.",

keywords = "Aconiti Tuber, Aconitine-type alkaloids, Buffer solution, Corni Fructus, Decoction",

author = "Masanori Taki and Kaoru Nakajima and Hiroshi Sasaki and Yasuhiro Komatsu and Minoru Okada and Takashi Itoh and Kazuhiko Nagasaka and Toshiaki Kita and Naotoshi Shibahara and Katsutoshi Terasawa",

note = "Funding Information: Acknowledgements. We thank Ms. Caccilia Kuhn and Ms. Frieder-ike Schmitt (Heidelberg) for invaluable technical and secretarial assistance. Thanks are also due to Dr. N.S. Gould (Chicago), who generously contributed several cases. This investigation was supported in part by the Deutschc Forschungsgcmeinschaft (grants to W.W.F., B.W., and R.M.) and by the Otho S.A. Sprague Memorial Fund (to V.E.G.).",

year = "1998",

language = "英語",

volume = "52",

pages = "434--439",

journal = "Natural Medicines",

issn = "1340-3443",

publisher = "Springer Japan",

number = "5",

}

TY - JOUR

T1 - Studies on the aconitine-type alkaloids in decoction of kampo prescriptions containing Aconiti Tuber

AU - Taki, Masanori

AU - Nakajima, Kaoru

AU - Sasaki, Hiroshi

AU - Komatsu, Yasuhiro

AU - Okada, Minoru

AU - Itoh, Takashi

AU - Nagasaka, Kazuhiko

AU - Kita, Toshiaki

AU - Shibahara, Naotoshi

AU - Terasawa, Katsutoshi

N1 - Funding Information: Acknowledgements. We thank Ms. Caccilia Kuhn and Ms. Frieder-ike Schmitt (Heidelberg) for invaluable technical and secretarial assistance. Thanks are also due to Dr. N.S. Gould (Chicago), who generously contributed several cases. This investigation was supported in part by the Deutschc Forschungsgcmeinschaft (grants to W.W.F., B.W., and R.M.) and by the Otho S.A. Sprague Memorial Fund (to V.E.G.).

PY - 1998

Y1 - 1998

N2 - When Aconiti Tuber (6g) was decocted with Corni Fructus (3g) in boiling water (800mL → 400mL), the total amount of the aconitine diester alkaloids in the decoction was 0.346mg and the pH value of the decoction was 5.1. When only Aconiti Tuber (6g) was decocted in citrate-hydrochloric acid buffer (pH4.0), the decoction contained 6.61mg of the alkaloids, and when it was decocted with water (pH7.8), the decoction contained 0.031mg of the alkaloids. The alkaloid content in a decoction prepared at pH4.0 was 200 times that in the decoction of pH7.8. These results suggest that the pH of decoction affects the hydrolysis reaction of the alkaloids in the decoction considerably.

AB - When Aconiti Tuber (6g) was decocted with Corni Fructus (3g) in boiling water (800mL → 400mL), the total amount of the aconitine diester alkaloids in the decoction was 0.346mg and the pH value of the decoction was 5.1. When only Aconiti Tuber (6g) was decocted in citrate-hydrochloric acid buffer (pH4.0), the decoction contained 6.61mg of the alkaloids, and when it was decocted with water (pH7.8), the decoction contained 0.031mg of the alkaloids. The alkaloid content in a decoction prepared at pH4.0 was 200 times that in the decoction of pH7.8. These results suggest that the pH of decoction affects the hydrolysis reaction of the alkaloids in the decoction considerably.

KW - Aconiti Tuber

KW - Aconitine-type alkaloids

KW - Buffer solution

KW - Corni Fructus

KW - Decoction

UR - http://www.scopus.com/inward/record.url?scp=0031789672&partnerID=8YFLogxK

M3 - 学術論文

AN - SCOPUS:0031789672

SN - 1340-3443

VL - 52

SP - 434

EP - 439

JO - Natural Medicines

JF - Natural Medicines

IS - 5

ER -

Studies on the aconitine-type alkaloids in decoction of kampo prescriptions containing Aconiti Tuber

Abstract

Keywords

ASJC Scopus subject areas

Fingerprint

Cite this