Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitors

J. Bouquet; N. Auberger; R. Ashmus; D. King; A. Bordes; N. Fontelle; S. Nakagawa; Z. Madden; C. Proceviat; A. Kato; J. Désiré; D. J. Vocadlo; Y. Blériot

doi:10.1039/d1ob02280f

Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitors

J. Bouquet, N. Auberger, R. Ashmus, D. King, A. Bordes, N. Fontelle, S. Nakagawa, Z. Madden, C. Proceviat, A. Kato, J. Désiré, D. J. Vocadlo, Y. Blériot

薬剤部

研究成果: ジャーナルへの寄稿 › 学術論文

4 被引用数 (Scopus)

抄録

Epimerization C-alkylation of a seven-membered iminosugar with a broad hexosaminidase inhibition spectrum leads to low micromolar HexAB and NagZ inhibitors.

寄稿の翻訳タイトル	Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitors
本文言語	未定義/不明
ページ（範囲）	619-629
ページ数	11
ジャーナル	Organic and Biomolecular Chemistry
巻	20
号	3
DOI	https://doi.org/10.1039/d1ob02280f
出版ステータス	出版済み - 2022/01

文献へのアクセス

10.1039/d1ob02280fライセンス: 指定なし

フィンガープリント

「Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitors」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

Bouquet, J., Auberger, N., Ashmus, R., King, D., Bordes, A., Fontelle, N., Nakagawa, S., Madden, Z., Proceviat, C., Kato, A., Désiré, J., Vocadlo, D. J., & Blériot, Y. (2022). Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitors. Organic and Biomolecular Chemistry, 20(3), 619-629. https://doi.org/10.1039/d1ob02280f

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abstract = "Epimerization C-alkylation of a seven-membered iminosugar with a broad hexosaminidase inhibition spectrum leads to low micromolar HexAB and NagZ inhibitors.",

author = "J. Bouquet and N. Auberger and R. Ashmus and D. King and A. Bordes and N. Fontelle and S. Nakagawa and Z. Madden and C. Proceviat and A. Kato and J. D{\'e}sir{\'e} and Vocadlo, {D. J.} and Y. Bl{\'e}riot",

year = "2022",

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doi = "10.1039/d1ob02280f",

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Bouquet, J, Auberger, N, Ashmus, R, King, D, Bordes, A, Fontelle, N, Nakagawa, S, Madden, Z, Proceviat, C, Kato, A, Désiré, J, Vocadlo, DJ & Blériot, Y 2022, 'Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitors', Organic and Biomolecular Chemistry, vol. 20, no. 3, pp. 619-629. https://doi.org/10.1039/d1ob02280f

TY - JOUR

T1 - Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitors

AU - Bouquet, J.

AU - Auberger, N.

AU - Ashmus, R.

AU - King, D.

AU - Bordes, A.

AU - Fontelle, N.

AU - Nakagawa, S.

AU - Madden, Z.

AU - Proceviat, C.

AU - Kato, A.

AU - Désiré, J.

AU - Vocadlo, D. J.

AU - Blériot, Y.

PY - 2022/1

Y1 - 2022/1

N2 - Epimerization C-alkylation of a seven-membered iminosugar with a broad hexosaminidase inhibition spectrum leads to low micromolar HexAB and NagZ inhibitors.

AB - Epimerization C-alkylation of a seven-membered iminosugar with a broad hexosaminidase inhibition spectrum leads to low micromolar HexAB and NagZ inhibitors.

U2 - 10.1039/d1ob02280f

DO - 10.1039/d1ob02280f

M3 - 学術論文

C2 - 34940771

SN - 1477-0520

VL - 20

SP - 619

EP - 629

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 3

ER -