Streamlined sensory motor communication through cortical reciprocal connectivity in a visually guided eye movement task

Takahide Itokazu, Masashi Hasegawa, Rui Kimura, Hironobu Osaki, Urban Raphael Albrecht, Kazuhiro Sohya, Shubhodeep Chakrabarti, Hideaki Itoh, Tetsufumi Ito, Tatsuo K. Sato*, Takashi R. Sato

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

57 被引用数 (Scopus)

抄録

Cortical computation is distributed across multiple areas of the cortex by networks of reciprocal connectivity. However, how such connectivity contributes to the communication between the connected areas is not clear. In this study, we examine the communication between sensory and motor cortices. We develop an eye movement task in mice and combine it with optogenetic suppression and two-photon calcium imaging techniques. We identify a small region in the secondary motor cortex (MOs) that controls eye movements and reciprocally connects with a rostrolateral part of the higher visual areas (VRL/A/AL). These two regions encode both motor signals and visual information; however, the information flow between the regions depends on the direction of the connectivity: motor information is conveyed preferentially from the MOs to the VRL/A/AL, and sensory information is transferred primarily in the opposite direction. We propose that reciprocal connectivity streamlines information flow, enhancing the computational capacity of a distributed network.

本文言語英語
論文番号338
ジャーナルNature Communications
9
1
DOI
出版ステータス出版済み - 2018/12/01

ASJC Scopus 主題領域

  • 化学一般
  • 生化学、遺伝学、分子生物学一般
  • 物理学および天文学一般

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