Stereoselective synthesis of the C1-C7 segment of (+)-discodermolide

Masahiro Miyazawa; Satoshi Oonuma; Kimiyuki Maruyama; Masaaki Miyashita

doi:10.1246/cl.1997.1191

Stereoselective synthesis of the C₁-C₇ segment of (+)-discodermolide

Masahiro Miyazawa, Satoshi Oonuma, Kimiyuki Maruyama, Masaaki Miyashita^*

^*この論文の責任著者

化学科

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

34 被引用数 (Scopus)

抄録

A new and highly stereoselective synthesis of the C₁-C₇ segment of (+)-discodermolide, the marine natural product having the potent immunosuppressive activity, is described in which the stereospecific methylation of γ,δ-epoxy acrylate with trimethyl-aluminum and the intramolecular conjugate addition of an acetal alkoxide anion are involved as key steps.

本文言語	英語
ページ（範囲）	1191-1192
ページ数	2
ジャーナル	Chemistry Letters
号	12
DOI	https://doi.org/10.1246/cl.1997.1191
出版ステータス	出版済み - 1997

ASJC Scopus 主題領域

化学一般

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

文献へのアクセス

10.1246/cl.1997.1191

引用スタイル

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title = "Stereoselective synthesis of the C1-C7 segment of (+)-discodermolide",

abstract = "A new and highly stereoselective synthesis of the C1-C7 segment of (+)-discodermolide, the marine natural product having the potent immunosuppressive activity, is described in which the stereospecific methylation of γ,δ-epoxy acrylate with trimethyl-aluminum and the intramolecular conjugate addition of an acetal alkoxide anion are involved as key steps.",

author = "Masahiro Miyazawa and Satoshi Oonuma and Kimiyuki Maruyama and Masaaki Miyashita",

year = "1997",

doi = "10.1246/cl.1997.1191",

language = "英語",

pages = "1191--1192",

journal = "Chemistry Letters",

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T1 - Stereoselective synthesis of the C1-C7 segment of (+)-discodermolide

AU - Miyazawa, Masahiro

AU - Oonuma, Satoshi

AU - Maruyama, Kimiyuki

AU - Miyashita, Masaaki

PY - 1997

Y1 - 1997

N2 - A new and highly stereoselective synthesis of the C1-C7 segment of (+)-discodermolide, the marine natural product having the potent immunosuppressive activity, is described in which the stereospecific methylation of γ,δ-epoxy acrylate with trimethyl-aluminum and the intramolecular conjugate addition of an acetal alkoxide anion are involved as key steps.

AB - A new and highly stereoselective synthesis of the C1-C7 segment of (+)-discodermolide, the marine natural product having the potent immunosuppressive activity, is described in which the stereospecific methylation of γ,δ-epoxy acrylate with trimethyl-aluminum and the intramolecular conjugate addition of an acetal alkoxide anion are involved as key steps.

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U2 - 10.1246/cl.1997.1191

DO - 10.1246/cl.1997.1191

M3 - 学術論文

AN - SCOPUS:0000888244

SN - 0366-7022

SP - 1191

EP - 1192

JO - Chemistry Letters

JF - Chemistry Letters

IS - 12

ER -