Stereoselective synthesis of the C1-C7 segment of (+)-discodermolide

Masahiro Miyazawa; Satoshi Oonuma; Kimiyuki Maruyama; Masaaki Miyashita

doi:10.1246/cl.1997.1191

Stereoselective synthesis of the C₁-C₇ segment of (+)-discodermolide

Masahiro Miyazawa, Satoshi Oonuma, Kimiyuki Maruyama, Masaaki Miyashita^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

A new and highly stereoselective synthesis of the C₁-C₇ segment of (+)-discodermolide, the marine natural product having the potent immunosuppressive activity, is described in which the stereospecific methylation of γ,δ-epoxy acrylate with trimethyl-aluminum and the intramolecular conjugate addition of an acetal alkoxide anion are involved as key steps.

Original language	English
Pages (from-to)	1191-1192
Number of pages	2
Journal	Chemistry Letters
Issue number	12
DOIs	https://doi.org/10.1246/cl.1997.1191
State	Published - 1997

ASJC Scopus subject areas

General Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1246/cl.1997.1191

Cite this

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title = "Stereoselective synthesis of the C1-C7 segment of (+)-discodermolide",

abstract = "A new and highly stereoselective synthesis of the C1-C7 segment of (+)-discodermolide, the marine natural product having the potent immunosuppressive activity, is described in which the stereospecific methylation of γ,δ-epoxy acrylate with trimethyl-aluminum and the intramolecular conjugate addition of an acetal alkoxide anion are involved as key steps.",

author = "Masahiro Miyazawa and Satoshi Oonuma and Kimiyuki Maruyama and Masaaki Miyashita",

year = "1997",

doi = "10.1246/cl.1997.1191",

language = "英語",

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journal = "Chemistry Letters",

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T1 - Stereoselective synthesis of the C1-C7 segment of (+)-discodermolide

AU - Miyazawa, Masahiro

AU - Oonuma, Satoshi

AU - Maruyama, Kimiyuki

AU - Miyashita, Masaaki

PY - 1997

Y1 - 1997

N2 - A new and highly stereoselective synthesis of the C1-C7 segment of (+)-discodermolide, the marine natural product having the potent immunosuppressive activity, is described in which the stereospecific methylation of γ,δ-epoxy acrylate with trimethyl-aluminum and the intramolecular conjugate addition of an acetal alkoxide anion are involved as key steps.

AB - A new and highly stereoselective synthesis of the C1-C7 segment of (+)-discodermolide, the marine natural product having the potent immunosuppressive activity, is described in which the stereospecific methylation of γ,δ-epoxy acrylate with trimethyl-aluminum and the intramolecular conjugate addition of an acetal alkoxide anion are involved as key steps.

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U2 - 10.1246/cl.1997.1191

DO - 10.1246/cl.1997.1191

M3 - 学術論文

AN - SCOPUS:0000888244

SN - 0366-7022

SP - 1191

EP - 1192

JO - Chemistry Letters

JF - Chemistry Letters

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