Spiruchostatin A and B, novel histone deacetylase inhibitors, induce apoptosis through reactive oxygen species-mitochondria pathway in human lymphoma U937 cells

Keyphrases

• Induced Apoptosis 100%
• Reactive Oxygen Species 100%
• Human Leukemia U937 Cells 100%
• Histone Deacetylase Inhibitor (HDACi) 100%
• Mitochondrial Pathway 100%
• Spiruchostatin 100%
• Apoptosis 17%
• Intracellular Reactive Oxygen Species 11%
• Mechanism of Action 5%
• Mitochondrial Membrane Potential 5%
• DNA Fragmentation 5%
• U937 Cells 5%
• Lethality 5%
• Chemotherapy 5%
• Reactive Oxygen Species Production 5%
• Caspase-8 5%
• Caspase-3 Activation 5%
• N-acetylcysteine 5%
• Nuclear Morphology 5%
• Cytochrome c (Cyt c) 5%
• Leukemia 5%
• Annexin V-FITC 5%
• DNA Modification 5%
• Novel Chemotherapeutic Agents 5%

Pharmacology, Toxicology and Pharmaceutical Science

• Reactive Oxygen Metabolite 100%
• Histone Deacetylase Inhibitor 100%
• Chemotherapy 20%
• Leukemia 20%
• Lipocortin 5 20%
• Caspase 3 20%
• Cytochrome C 20%
• Acetylcysteine 20%
• Fluorescein Isothiocyanate 20%
• Caspase 8 20%
• Lethality 20%