Specific induced circular dichroism and enhanced B to Z transitions of duplexes stabilized by chromophore-linked alkynylnucleoside residues

Kazuhisa Fujimoto*, Sayaka Aizawa, Ikko Oota, Junya Chiba, Masahiko Inouye

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

13 被引用数 (Scopus)

抄録

We have developed an induced circular dichroism (ICD) probe with a chromophore-linked alkynyldeoxyribose skeleton for analyzing higher-order structures of DNA duplexes in the visible-light region. When CG-repeated oligonucleotides (ODNs) with the probe at their 5' ends adopted Z-form duplexes at a high NaCl concentration, strong ICD signals were observed at the absorptive region of the chromophore. On the other hand, their B-form duplexes, formed at a low NaCl concentration, produced a faint ICD signal. The specific ICD for the Z-form duplexes was found to appear only when the chromophores were attached at the 5' ends of each of the ODNs. Furthermore, the chromophoric alkynylnucleoside residues effectively promoted the B to Z transition of the ODN.

本文言語英語
ページ(範囲)2401-2406
ページ数6
ジャーナルChemistry - A European Journal
16
8
DOI
出版ステータス出版済み - 2010/02/22

ASJC Scopus 主題領域

  • 触媒
  • 有機化学

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