抄録
We have developed an induced circular dichroism (ICD) probe with a chromophore-linked alkynyldeoxyribose skeleton for analyzing higher-order structures of DNA duplexes in the visible-light region. When CG-repeated oligonucleotides (ODNs) with the probe at their 5' ends adopted Z-form duplexes at a high NaCl concentration, strong ICD signals were observed at the absorptive region of the chromophore. On the other hand, their B-form duplexes, formed at a low NaCl concentration, produced a faint ICD signal. The specific ICD for the Z-form duplexes was found to appear only when the chromophores were attached at the 5' ends of each of the ODNs. Furthermore, the chromophoric alkynylnucleoside residues effectively promoted the B to Z transition of the ODN.
本文言語 | 英語 |
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ページ(範囲) | 2401-2406 |
ページ数 | 6 |
ジャーナル | Chemistry - A European Journal |
巻 | 16 |
号 | 8 |
DOI | |
出版ステータス | 出版済み - 2010/02/22 |
ASJC Scopus 主題領域
- 触媒
- 有機化学