Simulation for population pharmacodynamic analysis of dose-ranging trials: Usefulness of the mixture model analysis for detecting nonresponders

Takeshi Shiiki; Yukiya Hashimoto; Ken Ichi Inui

doi:10.1023/A:1016181505556

Simulation for population pharmacodynamic analysis of dose-ranging trials: Usefulness of the mixture model analysis for detecting nonresponders

Takeshi Shiiki, Yukiya Hashimoto, Ken Ichi Inui

医薬品安全性学研究室

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

5 被引用数 (Scopus)

本文言語	英語
ページ（範囲）	909-913
ページ数	5
ジャーナル	Pharmaceutical Research
巻	19
号	6
DOI	https://doi.org/10.1023/A:1016181505556
出版ステータス	出版済み - 2002

ASJC Scopus 主題領域

バイオテクノロジー
分子医療
薬理学
薬科学
有機化学
薬理学（医学）

文献へのアクセス

10.1023/A:1016181505556

引用スタイル

@article{883d66361c4c4aac9864d84e06108fce,

title = "Simulation for population pharmacodynamic analysis of dose-ranging trials: Usefulness of the mixture model analysis for detecting nonresponders",

keywords = "Dose-ranging trial, Mixture model, NONMEM, Non-responder, Population pharmacodynamics",

author = "Takeshi Shiiki and Yukiya Hashimoto and Inui, {Ken Ichi}",

note = "Funding Information: This work was supported in part by a grant-in-aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan and by grants from the Japan Research Foundation for Clinical Pharmacology.",

year = "2002",

doi = "10.1023/A:1016181505556",

language = "英語",

volume = "19",

pages = "909--913",

journal = "Pharmaceutical Research",

issn = "0724-8741",

publisher = "Springer",

number = "6",

}

TY - JOUR

T1 - Simulation for population pharmacodynamic analysis of dose-ranging trials

T2 - Usefulness of the mixture model analysis for detecting nonresponders

AU - Shiiki, Takeshi

AU - Hashimoto, Yukiya

AU - Inui, Ken Ichi

N1 - Funding Information: This work was supported in part by a grant-in-aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan and by grants from the Japan Research Foundation for Clinical Pharmacology.

PY - 2002

Y1 - 2002

KW - Dose-ranging trial

KW - Mixture model

KW - NONMEM

KW - Non-responder

KW - Population pharmacodynamics

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U2 - 10.1023/A:1016181505556

DO - 10.1023/A:1016181505556

M3 - 学術論文

C2 - 12134965

AN - SCOPUS:0036291820

SN - 0724-8741

VL - 19

SP - 909

EP - 913

JO - Pharmaceutical Research

JF - Pharmaceutical Research

IS - 6

ER -