Sex-Dependent Effects of the APOE ϵ4 Allele on Behavioral Traits and White Matter Structures in Young Adults

Hikaru Takeuchi; Hiroaki Tomita; Ryan Browne; Yasuyuki Taki; Yoshie Kikuchi; Chiaki Ono; Zhiqian Yu; Rui Nouchi; Ryoichi Yokoyama; Yuka Kotozaki; Seishu Nakagawa; Atsushi Sekiguchi; Kunio Iizuka; Sugiko Hanawa; Tsuyoshi Araki; Carlos Makoto Miyauchi; Kohei Sakaki; Takayuki Nozawa; Shigeyuki Ikeda; Susumu Yokota; Daniele Magistro; Yuko Sassa; Ryuta Kawashima

doi:10.1093/cercor/bhaa251

Sex-Dependent Effects of the APOE ϵ4 Allele on Behavioral Traits and White Matter Structures in Young Adults

Hikaru Takeuchi^*, Hiroaki Tomita, Ryan Browne, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu YokotaDaniele Magistro, Yuko Sassa, Ryuta Kawashima

^*この論文の責任著者

工学科　知能情報工学コース

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

7 被引用数 (Scopus)

抄録

The APOE ϵ4 allele is associated with a risk of Alzheimer's disease in the elderly, with the association being pronounced in females. Conversely, findings of the effects of the APOE ϵ4 allele in young adults are mixed. Here, we investigated the sex-genotype interaction effects of the APOE ϵ4 allele on cognitive functions as well as brain structures among 1258 young adults. After adjusting for multiple comparisons, there were significant effects of the interaction between sex and the number of APOE ϵ4 allele on some speed tasks (e.g., simple processing speed tasks and the reverse Stroop task) as well as on regional white matter volume (rWMV). The observed sex-genotype interaction conferred better cognitive performance and greater rWMV in the anterior frontal and precentral white matter areas in females having more APOE ϵ4 alleles and reduced rWMV in the same areas in male having more APOE ϵ4 alleles. These findings support the long-debated antagonistic pleiotropic effects of the APOE ϵ4 allele in females.

本文言語	英語
ページ（範囲）	672-680
ページ数	9
ジャーナル	Cerebral Cortex
巻	31
号	1
DOI	https://doi.org/10.1093/cercor/bhaa251
出版ステータス	出版済み - 2021/01/01

ASJC Scopus 主題領域

認知神経科学
細胞および分子神経科学

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10.1093/cercor/bhaa251

引用スタイル

Takeuchi, H., Tomita, H., Browne, R., Taki, Y., Kikuchi, Y., Ono, C., Yu, Z., Nouchi, R., Yokoyama, R., Kotozaki, Y., Nakagawa, S., Sekiguchi, A., Iizuka, K., Hanawa, S., Araki, T., Miyauchi, C. M., Sakaki, K., Nozawa, T., Ikeda, S., ... Kawashima, R. (2021). Sex-Dependent Effects of the APOE ϵ4 Allele on Behavioral Traits and White Matter Structures in Young Adults. Cerebral Cortex, 31(1), 672-680. https://doi.org/10.1093/cercor/bhaa251

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title = "Sex-Dependent Effects of the APOE ϵ4 Allele on Behavioral Traits and White Matter Structures in Young Adults",

abstract = "The APOE ϵ4 allele is associated with a risk of Alzheimer's disease in the elderly, with the association being pronounced in females. Conversely, findings of the effects of the APOE ϵ4 allele in young adults are mixed. Here, we investigated the sex-genotype interaction effects of the APOE ϵ4 allele on cognitive functions as well as brain structures among 1258 young adults. After adjusting for multiple comparisons, there were significant effects of the interaction between sex and the number of APOE ϵ4 allele on some speed tasks (e.g., simple processing speed tasks and the reverse Stroop task) as well as on regional white matter volume (rWMV). The observed sex-genotype interaction conferred better cognitive performance and greater rWMV in the anterior frontal and precentral white matter areas in females having more APOE ϵ4 alleles and reduced rWMV in the same areas in male having more APOE ϵ4 alleles. These findings support the long-debated antagonistic pleiotropic effects of the APOE ϵ4 allele in females.",

keywords = "APOE genotype, imaging genetics, sex interaction effects, white matter structures, young adults",

author = "Hikaru Takeuchi and Hiroaki Tomita and Ryan Browne and Yasuyuki Taki and Yoshie Kikuchi and Chiaki Ono and Zhiqian Yu and Rui Nouchi and Ryoichi Yokoyama and Yuka Kotozaki and Seishu Nakagawa and Atsushi Sekiguchi and Kunio Iizuka and Sugiko Hanawa and Tsuyoshi Araki and Miyauchi, {Carlos Makoto} and Kohei Sakaki and Takayuki Nozawa and Shigeyuki Ikeda and Susumu Yokota and Daniele Magistro and Yuko Sassa and Ryuta Kawashima",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s) 2020. Published by Oxford University Press.",

year = "2021",

month = jan,

day = "1",

doi = "10.1093/cercor/bhaa251",

language = "英語",

volume = "31",

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Takeuchi, H, Tomita, H, Browne, R, Taki, Y, Kikuchi, Y, Ono, C, Yu, Z, Nouchi, R, Yokoyama, R, Kotozaki, Y, Nakagawa, S, Sekiguchi, A, Iizuka, K, Hanawa, S, Araki, T, Miyauchi, CM, Sakaki, K, Nozawa, T , Ikeda, S, Yokota, S, Magistro, D, Sassa, Y & Kawashima, R 2021, 'Sex-Dependent Effects of the APOE ϵ4 Allele on Behavioral Traits and White Matter Structures in Young Adults', Cerebral Cortex, vol. 31, no. 1, pp. 672-680. https://doi.org/10.1093/cercor/bhaa251

TY - JOUR

T1 - Sex-Dependent Effects of the APOE ϵ4 Allele on Behavioral Traits and White Matter Structures in Young Adults

AU - Takeuchi, Hikaru

AU - Tomita, Hiroaki

AU - Browne, Ryan

AU - Taki, Yasuyuki

AU - Kikuchi, Yoshie

AU - Ono, Chiaki

AU - Yu, Zhiqian

AU - Nouchi, Rui

AU - Yokoyama, Ryoichi

AU - Kotozaki, Yuka

AU - Nakagawa, Seishu

AU - Sekiguchi, Atsushi

AU - Iizuka, Kunio

AU - Hanawa, Sugiko

AU - Araki, Tsuyoshi

AU - Miyauchi, Carlos Makoto

AU - Sakaki, Kohei

AU - Nozawa, Takayuki

AU - Ikeda, Shigeyuki

AU - Yokota, Susumu

AU - Magistro, Daniele

AU - Sassa, Yuko

AU - Kawashima, Ryuta

PY - 2021/1/1

Y1 - 2021/1/1

N2 - The APOE ϵ4 allele is associated with a risk of Alzheimer's disease in the elderly, with the association being pronounced in females. Conversely, findings of the effects of the APOE ϵ4 allele in young adults are mixed. Here, we investigated the sex-genotype interaction effects of the APOE ϵ4 allele on cognitive functions as well as brain structures among 1258 young adults. After adjusting for multiple comparisons, there were significant effects of the interaction between sex and the number of APOE ϵ4 allele on some speed tasks (e.g., simple processing speed tasks and the reverse Stroop task) as well as on regional white matter volume (rWMV). The observed sex-genotype interaction conferred better cognitive performance and greater rWMV in the anterior frontal and precentral white matter areas in females having more APOE ϵ4 alleles and reduced rWMV in the same areas in male having more APOE ϵ4 alleles. These findings support the long-debated antagonistic pleiotropic effects of the APOE ϵ4 allele in females.

AB - The APOE ϵ4 allele is associated with a risk of Alzheimer's disease in the elderly, with the association being pronounced in females. Conversely, findings of the effects of the APOE ϵ4 allele in young adults are mixed. Here, we investigated the sex-genotype interaction effects of the APOE ϵ4 allele on cognitive functions as well as brain structures among 1258 young adults. After adjusting for multiple comparisons, there were significant effects of the interaction between sex and the number of APOE ϵ4 allele on some speed tasks (e.g., simple processing speed tasks and the reverse Stroop task) as well as on regional white matter volume (rWMV). The observed sex-genotype interaction conferred better cognitive performance and greater rWMV in the anterior frontal and precentral white matter areas in females having more APOE ϵ4 alleles and reduced rWMV in the same areas in male having more APOE ϵ4 alleles. These findings support the long-debated antagonistic pleiotropic effects of the APOE ϵ4 allele in females.

KW - APOE genotype

KW - imaging genetics

KW - sex interaction effects

KW - white matter structures

KW - young adults

UR - http://www.scopus.com/inward/record.url?scp=85098454201&partnerID=8YFLogxK

U2 - 10.1093/cercor/bhaa251

DO - 10.1093/cercor/bhaa251

M3 - 学術論文

C2 - 32954402

AN - SCOPUS:85098454201

SN - 1047-3211

VL - 31

SP - 672

EP - 680

JO - Cerebral Cortex

JF - Cerebral Cortex

IS - 1

ER -

Sex-Dependent Effects of the APOE ϵ4 Allele on Behavioral Traits and White Matter Structures in Young Adults

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