Serine racemase knockout mice: Neurotoxicity, epilepsy, and schizophrenia

Ran Inoue*, Hisashi Mori

*この論文の責任著者

研究成果: 書籍の章/レポート/会議録査読

1 被引用数 (Scopus)

抄録

The mammalian brain contains high levels of D-serine, which acts as a coagonist at the glycine site of the N-methyl D-aspartate (NMDA)-type glutamate receptor (NMDAR). The synthesis of D-serine from l-serine is catalyzed by serine racemase (SR). To date, several SR knockout (KO) mouse strains have been established to elucidate the role of the SR-D-serine pathway in the regulation of NMDAR activity under both physiological and pathological conditions. Here, we will review the phenotypes of these SR-KO mice used as animal models of NMDAR-mediated neurotoxicity, epilepsy, and schizophrenia and discuss the mechanistic involvement of the SR-D-serine pathway in these neurological and psychiatric disorders.

本文言語英語
ホスト出版物のタイトルD-Amino Acids
ホスト出版物のサブタイトルPhysiology, Metabolism, and Application
出版社Springer Japan
ページ119-136
ページ数18
ISBN(電子版)9784431560777
ISBN(印刷版)9784431560753
DOI
出版ステータス出版済み - 2016/01/01

ASJC Scopus 主題領域

  • 生化学、遺伝学、分子生物学一般

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