抄録
The mammalian brain contains high levels of D-serine, which acts as a coagonist at the glycine site of the N-methyl D-aspartate (NMDA)-type glutamate receptor (NMDAR). The synthesis of D-serine from l-serine is catalyzed by serine racemase (SR). To date, several SR knockout (KO) mouse strains have been established to elucidate the role of the SR-D-serine pathway in the regulation of NMDAR activity under both physiological and pathological conditions. Here, we will review the phenotypes of these SR-KO mice used as animal models of NMDAR-mediated neurotoxicity, epilepsy, and schizophrenia and discuss the mechanistic involvement of the SR-D-serine pathway in these neurological and psychiatric disorders.
本文言語 | 英語 |
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ホスト出版物のタイトル | D-Amino Acids |
ホスト出版物のサブタイトル | Physiology, Metabolism, and Application |
出版社 | Springer Japan |
ページ | 119-136 |
ページ数 | 18 |
ISBN(電子版) | 9784431560777 |
ISBN(印刷版) | 9784431560753 |
DOI | |
出版ステータス | 出版済み - 2016/01/01 |
ASJC Scopus 主題領域
- 生化学、遺伝学、分子生物学一般