Serine racemase knockout mice: Neurotoxicity, epilepsy, and schizophrenia

Ran Inoue; Hisashi Mori

doi:10.1007/978-4-431-56077-7_8

Serine racemase knockout mice: Neurotoxicity, epilepsy, and schizophrenia

Ran Inoue^*, Hisashi Mori

^*Corresponding author for this work

Molecular Neuroscience

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

The mammalian brain contains high levels of D-serine, which acts as a coagonist at the glycine site of the N-methyl D-aspartate (NMDA)-type glutamate receptor (NMDAR). The synthesis of D-serine from l-serine is catalyzed by serine racemase (SR). To date, several SR knockout (KO) mouse strains have been established to elucidate the role of the SR-D-serine pathway in the regulation of NMDAR activity under both physiological and pathological conditions. Here, we will review the phenotypes of these SR-KO mice used as animal models of NMDAR-mediated neurotoxicity, epilepsy, and schizophrenia and discuss the mechanistic involvement of the SR-D-serine pathway in these neurological and psychiatric disorders.

Original language	English
Title of host publication	D-Amino Acids
Subtitle of host publication	Physiology, Metabolism, and Application
Publisher	Springer Japan
Pages	119-136
Number of pages	18
ISBN (Electronic)	9784431560777
ISBN (Print)	9784431560753
DOIs	https://doi.org/10.1007/978-4-431-56077-7_8
State	Published - 2016/01/01

Keywords

D-Serine
Epilepsy
Neurotoxicity
Schizophrenia
Serine racemase knockout

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/978-4-431-56077-7_8

Cite this

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abstract = "The mammalian brain contains high levels of D-serine, which acts as a coagonist at the glycine site of the N-methyl D-aspartate (NMDA)-type glutamate receptor (NMDAR). The synthesis of D-serine from l-serine is catalyzed by serine racemase (SR). To date, several SR knockout (KO) mouse strains have been established to elucidate the role of the SR-D-serine pathway in the regulation of NMDAR activity under both physiological and pathological conditions. Here, we will review the phenotypes of these SR-KO mice used as animal models of NMDAR-mediated neurotoxicity, epilepsy, and schizophrenia and discuss the mechanistic involvement of the SR-D-serine pathway in these neurological and psychiatric disorders.",

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Serine racemase knockout mice: Neurotoxicity, epilepsy, and schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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