SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus

Kimiko Shimizu*, Masato Okada, Atsuko Takano, Katsuya Nagai

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

69 被引用数 (Scopus)

抄録

To elucidate the mechanism of the circadian rhythm, genes differentially expressed during subjective day and night in the rat suprachiasmatic nucleus (SCN), a circadian oscillator in mammals, were surveyed by a differential display method. We isolated a novel gene, scop (SCN circadian oscillatory protein), that was expressed in a circadian manner in the SCN. SCOP protein is predominantly expressed in the brain and has domains including a pleckstrin homology domain, leucine-rich repeats, a protein phosphatase 2C-like domain and a glutamine-rich region. The structural feature of SCOP protein suggests its role in the intracellular signaling in the SCN. Copyright (C) 1999 Federation of European Biochemical Societies.

本文言語英語
ページ(範囲)363-369
ページ数7
ジャーナルFEBS Letters
458
3
DOI
出版ステータス出版済み - 1999/09/24

ASJC Scopus 主題領域

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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