抄録
To elucidate the mechanism of the circadian rhythm, genes differentially expressed during subjective day and night in the rat suprachiasmatic nucleus (SCN), a circadian oscillator in mammals, were surveyed by a differential display method. We isolated a novel gene, scop (SCN circadian oscillatory protein), that was expressed in a circadian manner in the SCN. SCOP protein is predominantly expressed in the brain and has domains including a pleckstrin homology domain, leucine-rich repeats, a protein phosphatase 2C-like domain and a glutamine-rich region. The structural feature of SCOP protein suggests its role in the intracellular signaling in the SCN. Copyright (C) 1999 Federation of European Biochemical Societies.
本文言語 | 英語 |
---|---|
ページ(範囲) | 363-369 |
ページ数 | 7 |
ジャーナル | FEBS Letters |
巻 | 458 |
号 | 3 |
DOI | |
出版ステータス | 出版済み - 1999/09/24 |
ASJC Scopus 主題領域
- 生物理学
- 構造生物学
- 生化学
- 分子生物学
- 遺伝学
- 細胞生物学