SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus

Kimiko Shimizu; Masato Okada; Atsuko Takano; Katsuya Nagai

doi:10.1016/S0014-5793(99)01190-4

SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus

Kimiko Shimizu^*, Masato Okada, Atsuko Takano, Katsuya Nagai

^*Corresponding author for this work

International IR / Security Export Control Division, Organization for International Education and Exchange

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

To elucidate the mechanism of the circadian rhythm, genes differentially expressed during subjective day and night in the rat suprachiasmatic nucleus (SCN), a circadian oscillator in mammals, were surveyed by a differential display method. We isolated a novel gene, scop (SCN circadian oscillatory protein), that was expressed in a circadian manner in the SCN. SCOP protein is predominantly expressed in the brain and has domains including a pleckstrin homology domain, leucine-rich repeats, a protein phosphatase 2C-like domain and a glutamine-rich region. The structural feature of SCOP protein suggests its role in the intracellular signaling in the SCN. Copyright (C) 1999 Federation of European Biochemical Societies.

Original language	English
Pages (from-to)	363-369
Number of pages	7
Journal	FEBS Letters
Volume	458
Issue number	3
DOIs	https://doi.org/10.1016/S0014-5793(99)01190-4
State	Published - 1999/09/24

Keywords

Circadian rhythm
Differential display
Leucine-rich repeat
Protein phosphatase 2C
Rat brain
Suprachiasmatic nucleus

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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title = "SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus",

abstract = "To elucidate the mechanism of the circadian rhythm, genes differentially expressed during subjective day and night in the rat suprachiasmatic nucleus (SCN), a circadian oscillator in mammals, were surveyed by a differential display method. We isolated a novel gene, scop (SCN circadian oscillatory protein), that was expressed in a circadian manner in the SCN. SCOP protein is predominantly expressed in the brain and has domains including a pleckstrin homology domain, leucine-rich repeats, a protein phosphatase 2C-like domain and a glutamine-rich region. The structural feature of SCOP protein suggests its role in the intracellular signaling in the SCN. Copyright (C) 1999 Federation of European Biochemical Societies.",

keywords = "Circadian rhythm, Differential display, Leucine-rich repeat, Protein phosphatase 2C, Rat brain, Suprachiasmatic nucleus",

author = "Kimiko Shimizu and Masato Okada and Atsuko Takano and Katsuya Nagai",

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T1 - SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus

AU - Shimizu, Kimiko

AU - Okada, Masato

AU - Takano, Atsuko

AU - Nagai, Katsuya

PY - 1999/9/24

Y1 - 1999/9/24

N2 - To elucidate the mechanism of the circadian rhythm, genes differentially expressed during subjective day and night in the rat suprachiasmatic nucleus (SCN), a circadian oscillator in mammals, were surveyed by a differential display method. We isolated a novel gene, scop (SCN circadian oscillatory protein), that was expressed in a circadian manner in the SCN. SCOP protein is predominantly expressed in the brain and has domains including a pleckstrin homology domain, leucine-rich repeats, a protein phosphatase 2C-like domain and a glutamine-rich region. The structural feature of SCOP protein suggests its role in the intracellular signaling in the SCN. Copyright (C) 1999 Federation of European Biochemical Societies.

AB - To elucidate the mechanism of the circadian rhythm, genes differentially expressed during subjective day and night in the rat suprachiasmatic nucleus (SCN), a circadian oscillator in mammals, were surveyed by a differential display method. We isolated a novel gene, scop (SCN circadian oscillatory protein), that was expressed in a circadian manner in the SCN. SCOP protein is predominantly expressed in the brain and has domains including a pleckstrin homology domain, leucine-rich repeats, a protein phosphatase 2C-like domain and a glutamine-rich region. The structural feature of SCOP protein suggests its role in the intracellular signaling in the SCN. Copyright (C) 1999 Federation of European Biochemical Societies.

KW - Circadian rhythm

KW - Differential display

KW - Leucine-rich repeat

KW - Protein phosphatase 2C

KW - Rat brain

KW - Suprachiasmatic nucleus

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SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus

Abstract

Keywords

ASJC Scopus subject areas

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