Role of adult neurogenesis in hippocampal-cortical memory consolidation

Takashi Kitamura, Kaoru Inokuchi*

*この論文の責任著者

研究成果: ジャーナルへの寄稿総説査読

78 被引用数 (Scopus)

抄録

Acquired memory is initially dependent on the hippocampus (HPC) for permanent memory formation. This hippocampal dependency of memory recall progressively decays with time, a process that is associated with a gradual increase in dependency upon cortical structures. This process is commonly referred to as systems consolidation theory. In this paper, we first review how memory becomes hippocampal dependent to cortical dependent with an emphasis on the interactions that occur between the HPC and cortex during systems consolidation. We also review the mechanisms underlying the gradual decay of HPC dependency during systems consolidation from the perspective of memory erasures by adult hippocampal neurogenesis. Finally, we discuss the relationship between systems consolidation and memory precision.

本文言語英語
論文番号13
ジャーナルMolecular Brain
7
1
DOI
出版ステータス出版済み - 2014/02/19

ASJC Scopus 主題領域

  • 分子生物学
  • 細胞および分子神経科学

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