Requirement for hippocampal CA3 NMDA receptors in artificial association of memory events stored in CA3 cell ensembles

Masanori Nomoto*, Noriaki Ohkawa, Kaoru Inokuchi*, Naoya Oishi

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

4 被引用数 (Scopus)

抄録

The N-methyl-d-aspartate receptors (NRs) in hippocampal CA3 are crucial for the synaptic transmission and plasticity within the CA3 recurrent circuit, which supports the hippocampal functions, such as pattern completion, and reverberatory association of sensory inputs. Previous study showed that synchronous activation of distinct cell populations in CA3, which correspond to distinct events, associated independent events, suggesting that the recurrent circuit expressing NRs in CA3 mediates the artificial association of memory events stored in CA3 ensembles. However, it is still unclear whether CA3 NRs are crucial for the artificial association of memory events stored in the CA3 ensembles. Here we report that the triple transgenic mice (cfos-tTA/KA1-Cre/NR1 flox/flox), which specifically lack NRs in the CA3 cell ensembles, showed impairment in artificial association between two events, which in control mice triggered artificial association. This result indicates that NRs in the hippocampal CA3 are required for the artificial association of memory events stored in the CA3 cell ensembles.

本文言語英語
論文番号12
ジャーナルMolecular Brain
16
1
DOI
出版ステータス出版済み - 2023/12

ASJC Scopus 主題領域

  • 分子生物学
  • 細胞および分子神経科学

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