Relationship between melanin-concentrating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus

Kouhei Matsuda; Kenji Kojima; Sei Ichi Shimakura; Tohru Miura; Minoru Uchiyama; Seiji Shioda; Hironori Ando; Akiyoshi Takahashi

doi:10.1016/j.cbpa.2008.10.002

Relationship between melanin-concentrating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus

Kouhei Matsuda^*, Kenji Kojima, Sei Ichi Shimakura, Tohru Miura, Minoru Uchiyama, Seiji Shioda, Hironori Ando, Akiyoshi Takahashi

^*この論文の責任著者

理学科　生物科学プログラム

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

28 被引用数 (Scopus)

抄録

Intracerebroventricular (ICV) administration of melanin-concentrating hormone (MCH) inhibits food intake in goldfish, unlike the orexigenic action in rodents, via the melanocortin system with suppression of neuropeptide Y (NPY) mRNA expression. We therefore investigated the neuronal relationship between MCH- and NPY-containing neurons in the goldfish brain, using a double-immunofluorescence method and confocal laser scanning microscopy. MCH- and NPY-like immunoreactivities were distributed throughout the brain. In particular, MCH-containing nerve fibers or endings lay in close apposition to NPY-containing neurons in a specific region of the hypothalamus, the nucleus posterioris periventricularis (NPPv). These observations suggest that MCH-containing neurons provide direct input to NPY-containing neurons in the NPPv of goldfish, and that MCH plays a crucial role in the regulation of feeding behavior as an anorexigenic neuropeptide, inhibiting the orexigenic activity of NPY.

本文言語	英語
ページ（範囲）	3-7
ページ数	5
ジャーナル	Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology
巻	153
号	1
DOI	https://doi.org/10.1016/j.cbpa.2008.10.002
出版ステータス	出版済み - 2009/05

ASJC Scopus 主題領域

生化学
生理学
水圏科学
動物科学および動物学
分子生物学

文献へのアクセス

10.1016/j.cbpa.2008.10.002

引用スタイル

Matsuda, K., Kojima, K., Shimakura, S. I., Miura, T., Uchiyama, M., Shioda, S., Ando, H., & Takahashi, A. (2009). Relationship between melanin-concentrating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus. Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology, 153(1), 3-7. https://doi.org/10.1016/j.cbpa.2008.10.002

@article{a6266f9256cc4c59923bae9429cc8cae,

title = "Relationship between melanin-concentrating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus",

abstract = "Intracerebroventricular (ICV) administration of melanin-concentrating hormone (MCH) inhibits food intake in goldfish, unlike the orexigenic action in rodents, via the melanocortin system with suppression of neuropeptide Y (NPY) mRNA expression. We therefore investigated the neuronal relationship between MCH- and NPY-containing neurons in the goldfish brain, using a double-immunofluorescence method and confocal laser scanning microscopy. MCH- and NPY-like immunoreactivities were distributed throughout the brain. In particular, MCH-containing nerve fibers or endings lay in close apposition to NPY-containing neurons in a specific region of the hypothalamus, the nucleus posterioris periventricularis (NPPv). These observations suggest that MCH-containing neurons provide direct input to NPY-containing neurons in the NPPv of goldfish, and that MCH plays a crucial role in the regulation of feeding behavior as an anorexigenic neuropeptide, inhibiting the orexigenic activity of NPY.",

keywords = "Brain, Food intake, Goldfish, Hypothalamus, MCH, NPY, Neuronal interaction",

author = "Kouhei Matsuda and Kenji Kojima and Shimakura, {Sei Ichi} and Tohru Miura and Minoru Uchiyama and Seiji Shioda and Hironori Ando and Akiyoshi Takahashi",

note = "Funding Information: This work was supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan (A.T., H.A., K.M., T.M., S.S.), and by research grants from the University of Toyama (K.M.), the Toyama Marine Biotechnology Association (K.M.), the Nissui Research Foundation (K.M.), and the Mishima Kaiun Memorial Foundation (K.M.).",

year = "2009",

month = may,

doi = "10.1016/j.cbpa.2008.10.002",

language = "英語",

volume = "153",

pages = "3--7",

journal = "Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology",

issn = "1095-6433",

publisher = "Elsevier Inc.",

number = "1",

}

Matsuda, K, Kojima, K, Shimakura, SI, Miura, T, Uchiyama, M, Shioda, S, Ando, H & Takahashi, A 2009, 'Relationship between melanin-concentrating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus', Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology, vol. 153, no. 1, pp. 3-7. https://doi.org/10.1016/j.cbpa.2008.10.002

Relationship between melanin-concentrating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus. / Matsuda, Kouhei; Kojima, Kenji; Shimakura, Sei Ichi その他.
In: Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology, Vol. 153, No. 1, 05.2009, p. 3-7.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

TY - JOUR

T1 - Relationship between melanin-concentrating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus

AU - Matsuda, Kouhei

AU - Kojima, Kenji

AU - Shimakura, Sei Ichi

AU - Miura, Tohru

AU - Uchiyama, Minoru

AU - Shioda, Seiji

AU - Ando, Hironori

AU - Takahashi, Akiyoshi

N1 - Funding Information: This work was supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan (A.T., H.A., K.M., T.M., S.S.), and by research grants from the University of Toyama (K.M.), the Toyama Marine Biotechnology Association (K.M.), the Nissui Research Foundation (K.M.), and the Mishima Kaiun Memorial Foundation (K.M.).

PY - 2009/5

Y1 - 2009/5

N2 - Intracerebroventricular (ICV) administration of melanin-concentrating hormone (MCH) inhibits food intake in goldfish, unlike the orexigenic action in rodents, via the melanocortin system with suppression of neuropeptide Y (NPY) mRNA expression. We therefore investigated the neuronal relationship between MCH- and NPY-containing neurons in the goldfish brain, using a double-immunofluorescence method and confocal laser scanning microscopy. MCH- and NPY-like immunoreactivities were distributed throughout the brain. In particular, MCH-containing nerve fibers or endings lay in close apposition to NPY-containing neurons in a specific region of the hypothalamus, the nucleus posterioris periventricularis (NPPv). These observations suggest that MCH-containing neurons provide direct input to NPY-containing neurons in the NPPv of goldfish, and that MCH plays a crucial role in the regulation of feeding behavior as an anorexigenic neuropeptide, inhibiting the orexigenic activity of NPY.

AB - Intracerebroventricular (ICV) administration of melanin-concentrating hormone (MCH) inhibits food intake in goldfish, unlike the orexigenic action in rodents, via the melanocortin system with suppression of neuropeptide Y (NPY) mRNA expression. We therefore investigated the neuronal relationship between MCH- and NPY-containing neurons in the goldfish brain, using a double-immunofluorescence method and confocal laser scanning microscopy. MCH- and NPY-like immunoreactivities were distributed throughout the brain. In particular, MCH-containing nerve fibers or endings lay in close apposition to NPY-containing neurons in a specific region of the hypothalamus, the nucleus posterioris periventricularis (NPPv). These observations suggest that MCH-containing neurons provide direct input to NPY-containing neurons in the NPPv of goldfish, and that MCH plays a crucial role in the regulation of feeding behavior as an anorexigenic neuropeptide, inhibiting the orexigenic activity of NPY.

KW - Brain

KW - Food intake

KW - Goldfish

KW - Hypothalamus

KW - MCH

KW - NPY

KW - Neuronal interaction

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U2 - 10.1016/j.cbpa.2008.10.002

DO - 10.1016/j.cbpa.2008.10.002

M3 - 学術論文

C2 - 18950727

AN - SCOPUS:64049084446

SN - 1095-6433

VL - 153

SP - 3

EP - 7

JO - Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology

JF - Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology

IS - 1

ER -

Relationship between melanin-concentrating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus

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