Relationship between melanin-concentrating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus

Kouhei Matsuda; Kenji Kojima; Sei Ichi Shimakura; Tohru Miura; Minoru Uchiyama; Seiji Shioda; Hironori Ando; Akiyoshi Takahashi

doi:10.1016/j.cbpa.2008.10.002

Relationship between melanin-concentrating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus

Kouhei Matsuda^*, Kenji Kojima, Sei Ichi Shimakura, Tohru Miura, Minoru Uchiyama, Seiji Shioda, Hironori Ando, Akiyoshi Takahashi

^*Corresponding author for this work

Program of Biological Science

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Intracerebroventricular (ICV) administration of melanin-concentrating hormone (MCH) inhibits food intake in goldfish, unlike the orexigenic action in rodents, via the melanocortin system with suppression of neuropeptide Y (NPY) mRNA expression. We therefore investigated the neuronal relationship between MCH- and NPY-containing neurons in the goldfish brain, using a double-immunofluorescence method and confocal laser scanning microscopy. MCH- and NPY-like immunoreactivities were distributed throughout the brain. In particular, MCH-containing nerve fibers or endings lay in close apposition to NPY-containing neurons in a specific region of the hypothalamus, the nucleus posterioris periventricularis (NPPv). These observations suggest that MCH-containing neurons provide direct input to NPY-containing neurons in the NPPv of goldfish, and that MCH plays a crucial role in the regulation of feeding behavior as an anorexigenic neuropeptide, inhibiting the orexigenic activity of NPY.

Original language	English
Pages (from-to)	3-7
Number of pages	5
Journal	Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology
Volume	153
Issue number	1
DOIs	https://doi.org/10.1016/j.cbpa.2008.10.002
State	Published - 2009/05

Keywords

Brain
Food intake
Goldfish
Hypothalamus
MCH
NPY
Neuronal interaction

ASJC Scopus subject areas

Biochemistry
Physiology
Aquatic Science
Animal Science and Zoology
Molecular Biology

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10.1016/j.cbpa.2008.10.002

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Matsuda, K., Kojima, K., Shimakura, S. I., Miura, T., Uchiyama, M., Shioda, S., Ando, H., & Takahashi, A. (2009). Relationship between melanin-concentrating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus. Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology, 153(1), 3-7. https://doi.org/10.1016/j.cbpa.2008.10.002

@article{a6266f9256cc4c59923bae9429cc8cae,

title = "Relationship between melanin-concentrating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus",

abstract = "Intracerebroventricular (ICV) administration of melanin-concentrating hormone (MCH) inhibits food intake in goldfish, unlike the orexigenic action in rodents, via the melanocortin system with suppression of neuropeptide Y (NPY) mRNA expression. We therefore investigated the neuronal relationship between MCH- and NPY-containing neurons in the goldfish brain, using a double-immunofluorescence method and confocal laser scanning microscopy. MCH- and NPY-like immunoreactivities were distributed throughout the brain. In particular, MCH-containing nerve fibers or endings lay in close apposition to NPY-containing neurons in a specific region of the hypothalamus, the nucleus posterioris periventricularis (NPPv). These observations suggest that MCH-containing neurons provide direct input to NPY-containing neurons in the NPPv of goldfish, and that MCH plays a crucial role in the regulation of feeding behavior as an anorexigenic neuropeptide, inhibiting the orexigenic activity of NPY.",

keywords = "Brain, Food intake, Goldfish, Hypothalamus, MCH, NPY, Neuronal interaction",

author = "Kouhei Matsuda and Kenji Kojima and Shimakura, {Sei Ichi} and Tohru Miura and Minoru Uchiyama and Seiji Shioda and Hironori Ando and Akiyoshi Takahashi",

note = "Funding Information: This work was supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan (A.T., H.A., K.M., T.M., S.S.), and by research grants from the University of Toyama (K.M.), the Toyama Marine Biotechnology Association (K.M.), the Nissui Research Foundation (K.M.), and the Mishima Kaiun Memorial Foundation (K.M.).",

year = "2009",

month = may,

doi = "10.1016/j.cbpa.2008.10.002",

language = "英語",

volume = "153",

pages = "3--7",

journal = "Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology",

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Matsuda, K, Kojima, K, Shimakura, SI, Miura, T, Uchiyama, M, Shioda, S, Ando, H & Takahashi, A 2009, 'Relationship between melanin-concentrating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus', Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology, vol. 153, no. 1, pp. 3-7. https://doi.org/10.1016/j.cbpa.2008.10.002

Relationship between melanin-concentrating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus. / Matsuda, Kouhei; Kojima, Kenji; Shimakura, Sei Ichi et al.
In: Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology, Vol. 153, No. 1, 05.2009, p. 3-7.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Relationship between melanin-concentrating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus

AU - Matsuda, Kouhei

AU - Kojima, Kenji

AU - Shimakura, Sei Ichi

AU - Miura, Tohru

AU - Uchiyama, Minoru

AU - Shioda, Seiji

AU - Ando, Hironori

AU - Takahashi, Akiyoshi

N1 - Funding Information: This work was supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan (A.T., H.A., K.M., T.M., S.S.), and by research grants from the University of Toyama (K.M.), the Toyama Marine Biotechnology Association (K.M.), the Nissui Research Foundation (K.M.), and the Mishima Kaiun Memorial Foundation (K.M.).

PY - 2009/5

Y1 - 2009/5

N2 - Intracerebroventricular (ICV) administration of melanin-concentrating hormone (MCH) inhibits food intake in goldfish, unlike the orexigenic action in rodents, via the melanocortin system with suppression of neuropeptide Y (NPY) mRNA expression. We therefore investigated the neuronal relationship between MCH- and NPY-containing neurons in the goldfish brain, using a double-immunofluorescence method and confocal laser scanning microscopy. MCH- and NPY-like immunoreactivities were distributed throughout the brain. In particular, MCH-containing nerve fibers or endings lay in close apposition to NPY-containing neurons in a specific region of the hypothalamus, the nucleus posterioris periventricularis (NPPv). These observations suggest that MCH-containing neurons provide direct input to NPY-containing neurons in the NPPv of goldfish, and that MCH plays a crucial role in the regulation of feeding behavior as an anorexigenic neuropeptide, inhibiting the orexigenic activity of NPY.

AB - Intracerebroventricular (ICV) administration of melanin-concentrating hormone (MCH) inhibits food intake in goldfish, unlike the orexigenic action in rodents, via the melanocortin system with suppression of neuropeptide Y (NPY) mRNA expression. We therefore investigated the neuronal relationship between MCH- and NPY-containing neurons in the goldfish brain, using a double-immunofluorescence method and confocal laser scanning microscopy. MCH- and NPY-like immunoreactivities were distributed throughout the brain. In particular, MCH-containing nerve fibers or endings lay in close apposition to NPY-containing neurons in a specific region of the hypothalamus, the nucleus posterioris periventricularis (NPPv). These observations suggest that MCH-containing neurons provide direct input to NPY-containing neurons in the NPPv of goldfish, and that MCH plays a crucial role in the regulation of feeding behavior as an anorexigenic neuropeptide, inhibiting the orexigenic activity of NPY.

KW - Brain

KW - Food intake

KW - Goldfish

KW - Hypothalamus

KW - MCH

KW - NPY

KW - Neuronal interaction

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U2 - 10.1016/j.cbpa.2008.10.002

DO - 10.1016/j.cbpa.2008.10.002

M3 - 学術論文

C2 - 18950727

AN - SCOPUS:64049084446

SN - 1095-6433

VL - 153

SP - 3

EP - 7

JO - Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology

JF - Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology

IS - 1

ER -

Relationship between melanin-concentrating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus

Abstract

Keywords

ASJC Scopus subject areas

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