Plasmapheresis affects T helper type-1/T helper type-2 balance of circulating peripheral lymphocytes

Hirofumi Goto; Hidenori Matsuo; Shunya Nakane; Hajime Izumoto; Takayasu Fukudome; Chiaki Kambara; Noritoshi Shibuya

doi:10.1046/j.1526-0968.2001.00386.x

Plasmapheresis affects T helper type-1/T helper type-2 balance of circulating peripheral lymphocytes

Hirofumi Goto, Hidenori Matsuo^*, Shunya Nakane, Hajime Izumoto, Takayasu Fukudome, Chiaki Kambara, Noritoshi Shibuya

^*この論文の責任著者

脳神経内科（神経内科）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

59 被引用数 (Scopus)

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Plasmapheresis not only removes humoral factors, but may also modulate cellular immunity. We investigated whether plasmapheresis influenced T helper type-1/T helper type-2 (Th1/Th2) cytokine-producing-cell balance in 3 patients with neuroimmunological disease. The production of interferon-γ (IFN-γ), interleukin-2 (IL-2), and IL-4 in the culture supernatant of peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 was assayed. In 2 of 3 patients, plasmapheresis (immuno-adsorption or plasma exchange) reduced Th1/Th2 cytokine ratio. The results may suggest that plasmapheresis induces a shift of Th1/Th2 balance in peripheral blood.

本文言語	英語
ページ（範囲）	494-496
ページ数	3
ジャーナル	Therapeutic Apheresis
巻	5
号	6
DOI	https://doi.org/10.1046/j.1526-0968.2001.00386.x
出版ステータス	出版済み - 2001

ASJC Scopus 主題領域

医学一般

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10.1046/j.1526-0968.2001.00386.x

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title = "Plasmapheresis affects T helper type-1/T helper type-2 balance of circulating peripheral lymphocytes",

abstract = "Plasmapheresis not only removes humoral factors, but may also modulate cellular immunity. We investigated whether plasmapheresis influenced T helper type-1/T helper type-2 (Th1/Th2) cytokine-producing-cell balance in 3 patients with neuroimmunological disease. The production of interferon-γ (IFN-γ), interleukin-2 (IL-2), and IL-4 in the culture supernatant of peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 was assayed. In 2 of 3 patients, plasmapheresis (immuno-adsorption or plasma exchange) reduced Th1/Th2 cytokine ratio. The results may suggest that plasmapheresis induces a shift of Th1/Th2 balance in peripheral blood.",

keywords = "Immunomodulation, Plasmapheresis, T helper type-1, T helper type-2",

author = "Hirofumi Goto and Hidenori Matsuo and Shunya Nakane and Hajime Izumoto and Takayasu Fukudome and Chiaki Kambara and Noritoshi Shibuya",

year = "2001",

doi = "10.1046/j.1526-0968.2001.00386.x",

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T1 - Plasmapheresis affects T helper type-1/T helper type-2 balance of circulating peripheral lymphocytes

AU - Goto, Hirofumi

AU - Matsuo, Hidenori

AU - Nakane, Shunya

AU - Izumoto, Hajime

AU - Fukudome, Takayasu

AU - Kambara, Chiaki

AU - Shibuya, Noritoshi

PY - 2001

Y1 - 2001

N2 - Plasmapheresis not only removes humoral factors, but may also modulate cellular immunity. We investigated whether plasmapheresis influenced T helper type-1/T helper type-2 (Th1/Th2) cytokine-producing-cell balance in 3 patients with neuroimmunological disease. The production of interferon-γ (IFN-γ), interleukin-2 (IL-2), and IL-4 in the culture supernatant of peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 was assayed. In 2 of 3 patients, plasmapheresis (immuno-adsorption or plasma exchange) reduced Th1/Th2 cytokine ratio. The results may suggest that plasmapheresis induces a shift of Th1/Th2 balance in peripheral blood.

AB - Plasmapheresis not only removes humoral factors, but may also modulate cellular immunity. We investigated whether plasmapheresis influenced T helper type-1/T helper type-2 (Th1/Th2) cytokine-producing-cell balance in 3 patients with neuroimmunological disease. The production of interferon-γ (IFN-γ), interleukin-2 (IL-2), and IL-4 in the culture supernatant of peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 was assayed. In 2 of 3 patients, plasmapheresis (immuno-adsorption or plasma exchange) reduced Th1/Th2 cytokine ratio. The results may suggest that plasmapheresis induces a shift of Th1/Th2 balance in peripheral blood.

KW - Immunomodulation

KW - Plasmapheresis

KW - T helper type-1

KW - T helper type-2

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Plasmapheresis affects T helper type-1/T helper type-2 balance of circulating peripheral lymphocytes

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