Plasmapheresis affects T helper type-1/T helper type-2 balance of circulating peripheral lymphocytes

Hirofumi Goto; Hidenori Matsuo; Shunya Nakane; Hajime Izumoto; Takayasu Fukudome; Chiaki Kambara; Noritoshi Shibuya

doi:10.1046/j.1526-0968.2001.00386.x

Plasmapheresis affects T helper type-1/T helper type-2 balance of circulating peripheral lymphocytes

Hirofumi Goto, Hidenori Matsuo^*, Shunya Nakane, Hajime Izumoto, Takayasu Fukudome, Chiaki Kambara, Noritoshi Shibuya

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

Plasmapheresis not only removes humoral factors, but may also modulate cellular immunity. We investigated whether plasmapheresis influenced T helper type-1/T helper type-2 (Th1/Th2) cytokine-producing-cell balance in 3 patients with neuroimmunological disease. The production of interferon-γ (IFN-γ), interleukin-2 (IL-2), and IL-4 in the culture supernatant of peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 was assayed. In 2 of 3 patients, plasmapheresis (immuno-adsorption or plasma exchange) reduced Th1/Th2 cytokine ratio. The results may suggest that plasmapheresis induces a shift of Th1/Th2 balance in peripheral blood.

Original language	English
Pages (from-to)	494-496
Number of pages	3
Journal	Therapeutic Apheresis
Volume	5
Issue number	6
DOIs	https://doi.org/10.1046/j.1526-0968.2001.00386.x
State	Published - 2001

Keywords

Immunomodulation
Plasmapheresis
T helper type-1
T helper type-2

ASJC Scopus subject areas

General Medicine

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10.1046/j.1526-0968.2001.00386.x

Cite this

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title = "Plasmapheresis affects T helper type-1/T helper type-2 balance of circulating peripheral lymphocytes",

abstract = "Plasmapheresis not only removes humoral factors, but may also modulate cellular immunity. We investigated whether plasmapheresis influenced T helper type-1/T helper type-2 (Th1/Th2) cytokine-producing-cell balance in 3 patients with neuroimmunological disease. The production of interferon-γ (IFN-γ), interleukin-2 (IL-2), and IL-4 in the culture supernatant of peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 was assayed. In 2 of 3 patients, plasmapheresis (immuno-adsorption or plasma exchange) reduced Th1/Th2 cytokine ratio. The results may suggest that plasmapheresis induces a shift of Th1/Th2 balance in peripheral blood.",

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AU - Goto, Hirofumi

AU - Matsuo, Hidenori

AU - Nakane, Shunya

AU - Izumoto, Hajime

AU - Fukudome, Takayasu

AU - Kambara, Chiaki

AU - Shibuya, Noritoshi

PY - 2001

Y1 - 2001

N2 - Plasmapheresis not only removes humoral factors, but may also modulate cellular immunity. We investigated whether plasmapheresis influenced T helper type-1/T helper type-2 (Th1/Th2) cytokine-producing-cell balance in 3 patients with neuroimmunological disease. The production of interferon-γ (IFN-γ), interleukin-2 (IL-2), and IL-4 in the culture supernatant of peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 was assayed. In 2 of 3 patients, plasmapheresis (immuno-adsorption or plasma exchange) reduced Th1/Th2 cytokine ratio. The results may suggest that plasmapheresis induces a shift of Th1/Th2 balance in peripheral blood.

AB - Plasmapheresis not only removes humoral factors, but may also modulate cellular immunity. We investigated whether plasmapheresis influenced T helper type-1/T helper type-2 (Th1/Th2) cytokine-producing-cell balance in 3 patients with neuroimmunological disease. The production of interferon-γ (IFN-γ), interleukin-2 (IL-2), and IL-4 in the culture supernatant of peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 was assayed. In 2 of 3 patients, plasmapheresis (immuno-adsorption or plasma exchange) reduced Th1/Th2 cytokine ratio. The results may suggest that plasmapheresis induces a shift of Th1/Th2 balance in peripheral blood.

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KW - T helper type-2

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Plasmapheresis affects T helper type-1/T helper type-2 balance of circulating peripheral lymphocytes

Abstract

Keywords

ASJC Scopus subject areas

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