PACAP as a neuroprotective factor in ischemic neuronal injuries

Seiji Shioda; Tomoya Nakamachi

doi:10.1016/j.peptides.2015.08.006

PACAP as a neuroprotective factor in ischemic neuronal injuries

Seiji Shioda^*, Tomoya Nakamachi

^*この論文の責任著者

生物学科

研究成果: ジャーナルへの寄稿 › 総説 › 査読

56 被引用数 (Scopus)

抄録

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin family. PACAP and its three receptor subtypes are expressed in neural tissues, with PACAP known to exert pleiotropic effects on the nervous system. This review provides an overview of current knowledge regarding the neuroprotective effects, mechanisms of action, and therapeutic potential of PACAP in response to ischemic brain injuries.

本文言語	英語
ページ（範囲）	202-207
ページ数	6
ジャーナル	Peptides
巻	72
DOI	https://doi.org/10.1016/j.peptides.2015.08.006
出版ステータス	出版済み - 2015/10/01

ASJC Scopus 主題領域

生化学
生理学
内分泌学
細胞および分子神経科学

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10.1016/j.peptides.2015.08.006

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title = "PACAP as a neuroprotective factor in ischemic neuronal injuries",

abstract = "Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin family. PACAP and its three receptor subtypes are expressed in neural tissues, with PACAP known to exert pleiotropic effects on the nervous system. This review provides an overview of current knowledge regarding the neuroprotective effects, mechanisms of action, and therapeutic potential of PACAP in response to ischemic brain injuries.",

keywords = "CRMP2, DNA microarray analysis, Ischemia, Neuronal death, PACAP, PACAP receptors",

author = "Seiji Shioda and Tomoya Nakamachi",

note = "Publisher Copyright: {\textcopyright} 2015 Published by Elsevier Inc.",

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doi = "10.1016/j.peptides.2015.08.006",

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AU - Nakamachi, Tomoya

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin family. PACAP and its three receptor subtypes are expressed in neural tissues, with PACAP known to exert pleiotropic effects on the nervous system. This review provides an overview of current knowledge regarding the neuroprotective effects, mechanisms of action, and therapeutic potential of PACAP in response to ischemic brain injuries.

AB - Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin family. PACAP and its three receptor subtypes are expressed in neural tissues, with PACAP known to exert pleiotropic effects on the nervous system. This review provides an overview of current knowledge regarding the neuroprotective effects, mechanisms of action, and therapeutic potential of PACAP in response to ischemic brain injuries.

KW - CRMP2

KW - DNA microarray analysis

KW - Ischemia

KW - Neuronal death

KW - PACAP

KW - PACAP receptors

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M3 - 総説

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AN - SCOPUS:84946555745

SN - 0196-9781

VL - 72

SP - 202

EP - 207

JO - Peptides

JF - Peptides

ER -

PACAP as a neuroprotective factor in ischemic neuronal injuries

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