PACAP as a neuroprotective factor in ischemic neuronal injuries

Seiji Shioda; Tomoya Nakamachi

doi:10.1016/j.peptides.2015.08.006

PACAP as a neuroprotective factor in ischemic neuronal injuries

Seiji Shioda^*, Tomoya Nakamachi

^*Corresponding author for this work

Department of Biology

Research output: Contribution to journal › Review article › peer-review

56 Scopus citations

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin family. PACAP and its three receptor subtypes are expressed in neural tissues, with PACAP known to exert pleiotropic effects on the nervous system. This review provides an overview of current knowledge regarding the neuroprotective effects, mechanisms of action, and therapeutic potential of PACAP in response to ischemic brain injuries.

Original language	English
Pages (from-to)	202-207
Number of pages	6
Journal	Peptides
Volume	72
DOIs	https://doi.org/10.1016/j.peptides.2015.08.006
State	Published - 2015/10/01

Keywords

CRMP2
DNA microarray analysis
Ischemia
Neuronal death
PACAP
PACAP receptors

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/j.peptides.2015.08.006

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title = "PACAP as a neuroprotective factor in ischemic neuronal injuries",

abstract = "Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin family. PACAP and its three receptor subtypes are expressed in neural tissues, with PACAP known to exert pleiotropic effects on the nervous system. This review provides an overview of current knowledge regarding the neuroprotective effects, mechanisms of action, and therapeutic potential of PACAP in response to ischemic brain injuries.",

keywords = "CRMP2, DNA microarray analysis, Ischemia, Neuronal death, PACAP, PACAP receptors",

author = "Seiji Shioda and Tomoya Nakamachi",

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AU - Shioda, Seiji

AU - Nakamachi, Tomoya

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin family. PACAP and its three receptor subtypes are expressed in neural tissues, with PACAP known to exert pleiotropic effects on the nervous system. This review provides an overview of current knowledge regarding the neuroprotective effects, mechanisms of action, and therapeutic potential of PACAP in response to ischemic brain injuries.

AB - Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin family. PACAP and its three receptor subtypes are expressed in neural tissues, with PACAP known to exert pleiotropic effects on the nervous system. This review provides an overview of current knowledge regarding the neuroprotective effects, mechanisms of action, and therapeutic potential of PACAP in response to ischemic brain injuries.

KW - CRMP2

KW - DNA microarray analysis

KW - Ischemia

KW - Neuronal death

KW - PACAP

KW - PACAP receptors

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DO - 10.1016/j.peptides.2015.08.006

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VL - 72

SP - 202

EP - 207

JO - Peptides

JF - Peptides

ER -

PACAP as a neuroprotective factor in ischemic neuronal injuries

Abstract

Keywords

ASJC Scopus subject areas

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