Opposing regulation of B cell receptor-induced activation of mitogen-activated protein kinases by CD45

Mami Ogimoto, Yutaka Arimura, Tatsuo Katagiri, Katsuyuki Mitomo, James R. Woodgett, Angel R. Nebreda, Kazuya Mizuno, Hidetaka Yakura*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

11 被引用数 (Scopus)

抄録

In this study, we examined the contribution made by CD45 to B cell antigen receptor (BCR)-induced activation of mitogen-activated protein kinase (MAPK) family members. We found that CD45 negatively regulated BCR-induced c-Jun NH2-terminal kinase (JNK) and p38 activation in immature WEHI-231 cells, whereas in mature BAL-17 cells, CD45 positively regulated JNK and p38 activation and negatively regulated extracellular signal-regulated kinase activity. Furthermore, cooperative action of JNK and p38 dictated BCR-induced inhibition of growth. Thus, CD45 appears to differentially regulate BCR-induced activation of MAPK members, and can exert opposing effects on JNK and p38 in different cellular milieu, controlling the B cell fate.

本文言語英語
ページ(範囲)97-101
ページ数5
ジャーナルFEBS Letters
490
1-2
DOI
出版ステータス出版済み - 2001/02/09

ASJC Scopus 主題領域

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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