Opposing regulation of B cell receptor-induced activation of mitogen-activated protein kinases by CD45

Mami Ogimoto; Yutaka Arimura; Tatsuo Katagiri; Katsuyuki Mitomo; James R. Woodgett; Angel R. Nebreda; Kazuya Mizuno; Hidetaka Yakura

doi:10.1016/S0014-5793(00)02416-9

Opposing regulation of B cell receptor-induced activation of mitogen-activated protein kinases by CD45

Mami Ogimoto, Yutaka Arimura, Tatsuo Katagiri, Katsuyuki Mitomo, James R. Woodgett, Angel R. Nebreda, Kazuya Mizuno, Hidetaka Yakura^*

^*この論文の責任著者

教養教育学系

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

11 被引用数 (Scopus)

抄録

In this study, we examined the contribution made by CD45 to B cell antigen receptor (BCR)-induced activation of mitogen-activated protein kinase (MAPK) family members. We found that CD45 negatively regulated BCR-induced c-Jun NH₂-terminal kinase (JNK) and p38 activation in immature WEHI-231 cells, whereas in mature BAL-17 cells, CD45 positively regulated JNK and p38 activation and negatively regulated extracellular signal-regulated kinase activity. Furthermore, cooperative action of JNK and p38 dictated BCR-induced inhibition of growth. Thus, CD45 appears to differentially regulate BCR-induced activation of MAPK members, and can exert opposing effects on JNK and p38 in different cellular milieu, controlling the B cell fate.

本文言語	英語
ページ（範囲）	97-101
ページ数	5
ジャーナル	FEBS Letters
巻	490
号	1-2
DOI	https://doi.org/10.1016/S0014-5793(00)02416-9
出版ステータス	出版済み - 2001/02/09

ASJC Scopus 主題領域

生物理学
構造生物学
生化学
分子生物学
遺伝学
細胞生物学

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10.1016/S0014-5793(00)02416-9

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@article{274de65728d04c42aed5144191430571,

title = "Opposing regulation of B cell receptor-induced activation of mitogen-activated protein kinases by CD45",

abstract = "In this study, we examined the contribution made by CD45 to B cell antigen receptor (BCR)-induced activation of mitogen-activated protein kinase (MAPK) family members. We found that CD45 negatively regulated BCR-induced c-Jun NH2-terminal kinase (JNK) and p38 activation in immature WEHI-231 cells, whereas in mature BAL-17 cells, CD45 positively regulated JNK and p38 activation and negatively regulated extracellular signal-regulated kinase activity. Furthermore, cooperative action of JNK and p38 dictated BCR-induced inhibition of growth. Thus, CD45 appears to differentially regulate BCR-induced activation of MAPK members, and can exert opposing effects on JNK and p38 in different cellular milieu, controlling the B cell fate.",

keywords = "B lymphocyte, CD45, Mitogen-activated protein kinase, Protein tyrosine phosphatase, Signal transduction",

author = "Mami Ogimoto and Yutaka Arimura and Tatsuo Katagiri and Katsuyuki Mitomo and Woodgett, {James R.} and Nebreda, {Angel R.} and Kazuya Mizuno and Hidetaka Yakura",

note = "Funding Information: We thank Dr. Gary Koretzky for valuable reagents and Dr. Gema Alonso for critical technical advice. This work was supported in part by Grants-in-Aid for Scientific Research and for International Scientific Research from the Ministry of Education, Science, Sports and Culture.",

year = "2001",

month = feb,

day = "9",

doi = "10.1016/S0014-5793(00)02416-9",

language = "英語",

volume = "490",

pages = "97--101",

journal = "FEBS Letters",

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TY - JOUR

T1 - Opposing regulation of B cell receptor-induced activation of mitogen-activated protein kinases by CD45

AU - Ogimoto, Mami

AU - Arimura, Yutaka

AU - Katagiri, Tatsuo

AU - Mitomo, Katsuyuki

AU - Woodgett, James R.

AU - Nebreda, Angel R.

AU - Mizuno, Kazuya

AU - Yakura, Hidetaka

N1 - Funding Information: We thank Dr. Gary Koretzky for valuable reagents and Dr. Gema Alonso for critical technical advice. This work was supported in part by Grants-in-Aid for Scientific Research and for International Scientific Research from the Ministry of Education, Science, Sports and Culture.

PY - 2001/2/9

Y1 - 2001/2/9

N2 - In this study, we examined the contribution made by CD45 to B cell antigen receptor (BCR)-induced activation of mitogen-activated protein kinase (MAPK) family members. We found that CD45 negatively regulated BCR-induced c-Jun NH2-terminal kinase (JNK) and p38 activation in immature WEHI-231 cells, whereas in mature BAL-17 cells, CD45 positively regulated JNK and p38 activation and negatively regulated extracellular signal-regulated kinase activity. Furthermore, cooperative action of JNK and p38 dictated BCR-induced inhibition of growth. Thus, CD45 appears to differentially regulate BCR-induced activation of MAPK members, and can exert opposing effects on JNK and p38 in different cellular milieu, controlling the B cell fate.

AB - In this study, we examined the contribution made by CD45 to B cell antigen receptor (BCR)-induced activation of mitogen-activated protein kinase (MAPK) family members. We found that CD45 negatively regulated BCR-induced c-Jun NH2-terminal kinase (JNK) and p38 activation in immature WEHI-231 cells, whereas in mature BAL-17 cells, CD45 positively regulated JNK and p38 activation and negatively regulated extracellular signal-regulated kinase activity. Furthermore, cooperative action of JNK and p38 dictated BCR-induced inhibition of growth. Thus, CD45 appears to differentially regulate BCR-induced activation of MAPK members, and can exert opposing effects on JNK and p38 in different cellular milieu, controlling the B cell fate.

KW - B lymphocyte

KW - CD45

KW - Mitogen-activated protein kinase

KW - Protein tyrosine phosphatase

KW - Signal transduction

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U2 - 10.1016/S0014-5793(00)02416-9

DO - 10.1016/S0014-5793(00)02416-9

M3 - 学術論文

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AN - SCOPUS:0035830736

SN - 0014-5793

VL - 490

SP - 97

EP - 101

JO - FEBS Letters

JF - FEBS Letters

IS - 1-2

ER -

Opposing regulation of B cell receptor-induced activation of mitogen-activated protein kinases by CD45

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