@article{082e8220b51a494ab74347a3df00ce7a,
title = "Novel 2-aryl-3,4,5-trihydroxypiperidines: Synthesis and glycosidase inhibition",
abstract = "Three pairs of novel 2-aryl-3,4,5-trihydroxypiperidines (6-8 and their enantiomers), the piperidine analogues of the pyrrolidine alkaloids radicamine A and radicamine B, were prepared from six-membered cyclic nitrones through a concise two-step procedure, i.e., Grignard reagent addition and deprotection. These novel polyhydroxylated piperidine iminosugars were assayed against 10 types of enzymes. Only compound 8 exhibited weak inhibition (IC50 1080 μmol/L) against β-galactosidase from rat intestinal lactases.",
keywords = "2-Aryl polyhydroxylated piperidine, Glycosidase inhibitors, Iminosugars, Radicamine mimics",
author = "Hui Zhao and Wang, {Wu Bao} and Shinpei Nakagawa and Jia, {Yue Mei} and Hu, {Xiang Guo} and Fleet, {George W.J.} and Wilson, {Francis X.} and Nash, {Robert J.} and Atsushi Kato and Yu, {Chu Yi}",
note = "Funding Information: Financial support from National Basic Research Program of China (Nos. 2012CB822101 and 2011CB808603 ), and the Natural Science Foundation of China (Nos. 21272240 and 21102149 ) is gratefully acknowledged. ",
year = "2013",
month = dec,
doi = "10.1016/j.cclet.2013.06.027",
language = "英語",
volume = "24",
pages = "1059--1063",
journal = "Chinese Chemical Letters",
issn = "1001-8417",
publisher = "Elsevier B.V.",
number = "12",
}