TY - CHAP
T1 - Neurotensin
AU - Konno, Norifumi
N1 - Publisher Copyright:
© 2021 Elsevier Inc. All rights reserved.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Neurotensin (NT) was originally isolated from extracts of bovine hypothalamus in 1973, based on hypotensive action and peripheral vasodilation. The highly conserved C-terminal portion (8-13) of NT is responsible for its biological activities. NT is a neuromodulator of dopamine transmission and anterior pituitary hormone release, and exerts potent hypothermic and analgesic effects in the brain. In the periphery, NT acts as an endocrine modulator of the digestive tract and cardiovascular system, and as a growth factor on various normal or cancer cells. These functions are regulated via three receptors, NTR1, NTR2, and NTR3. NT is related to the pathophysiology of a series of disorders such as schizophrenia, drug abuse, Parkinson’s disease (PD), feeding disorders, cancer, cerebral stroke, and other neurodegenerative diseases. Furthermore, NT is involved in the physiology of pain induction, the central control of blood pressure, and inflammation.
AB - Neurotensin (NT) was originally isolated from extracts of bovine hypothalamus in 1973, based on hypotensive action and peripheral vasodilation. The highly conserved C-terminal portion (8-13) of NT is responsible for its biological activities. NT is a neuromodulator of dopamine transmission and anterior pituitary hormone release, and exerts potent hypothermic and analgesic effects in the brain. In the periphery, NT acts as an endocrine modulator of the digestive tract and cardiovascular system, and as a growth factor on various normal or cancer cells. These functions are regulated via three receptors, NTR1, NTR2, and NTR3. NT is related to the pathophysiology of a series of disorders such as schizophrenia, drug abuse, Parkinson’s disease (PD), feeding disorders, cancer, cerebral stroke, and other neurodegenerative diseases. Furthermore, NT is involved in the physiology of pain induction, the central control of blood pressure, and inflammation.
KW - Hypotensive effect
KW - Neurotensin (NT)
KW - Neurotensin receptor (NTR)
UR - http://www.scopus.com/inward/record.url?scp=85128054776&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-820649-2.00039-5
DO - 10.1016/B978-0-12-820649-2.00039-5
M3 - 章
AN - SCOPUS:85128054776
SP - 145
EP - 148
BT - Handbook of Hormones
PB - Elsevier
ER -
