@article{2d9fbb113288413fa4442469df3b0772,
title = "Muchimangins A-D: Novel diphenylmethyl-substituted xanthones from Securidaca longepedunculata",
abstract = "Four new highly oxygenated xanthones, named muchimangins A-D (1-4), with a diphenylmethyl substituent have been isolated as extremely minor constituents from the root of Securidaca longepedunculata (Polygalaceae). Among them, muchimangin B (2) induced an apoptotic-like cell death of human pancreatic cancer PANC-1 cell line preferentially in nutrient deprived condition with PC50 of 38.9 lM.",
keywords = "Congolese medicinal plant, Pancreatic cancer, Preferential cytotoxicity, Securidaca longepedunculata, Xanthone",
author = "Dibwe, {Dya Fita} and Suresh Awale and Shigetoshi Kadota and Yasuhiro Tezuka",
note = "Funding Information: Parts of this work were supported by a grant from the Ministry of Health and Welfare for the Third Term Comprehensive 10 year Strategy for Cancer Control and a research program of the Project for Development of Innovative Research on Cancer Therapeutics (P-Direct). ",
year = "2012",
month = nov,
day = "14",
doi = "10.1016/j.tetlet.2012.08.115",
language = "英語",
volume = "53",
pages = "6186--6190",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Ltd.",
number = "46",
}
