Muchimangins A-D: Novel diphenylmethyl-substituted xanthones from Securidaca longepedunculata

Dya Fita Dibwe; Suresh Awale; Shigetoshi Kadota; Yasuhiro Tezuka

doi:10.1016/j.tetlet.2012.08.115

Muchimangins A-D: Novel diphenylmethyl-substituted xanthones from Securidaca longepedunculata

Dya Fita Dibwe, Suresh Awale, Shigetoshi Kadota, Yasuhiro Tezuka^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Four new highly oxygenated xanthones, named muchimangins A-D (1-4), with a diphenylmethyl substituent have been isolated as extremely minor constituents from the root of Securidaca longepedunculata (Polygalaceae). Among them, muchimangin B (2) induced an apoptotic-like cell death of human pancreatic cancer PANC-1 cell line preferentially in nutrient deprived condition with PC50 of 38.9 lM.

Original language	English
Pages (from-to)	6186-6190
Number of pages	5
Journal	Tetrahedron Letters
Volume	53
Issue number	46
DOIs	https://doi.org/10.1016/j.tetlet.2012.08.115
State	Published - 2012/11/14

Keywords

Congolese medicinal plant
Pancreatic cancer
Preferential cytotoxicity
Securidaca longepedunculata
Xanthone

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tetlet.2012.08.115

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title = "Muchimangins A-D: Novel diphenylmethyl-substituted xanthones from Securidaca longepedunculata",

abstract = "Four new highly oxygenated xanthones, named muchimangins A-D (1-4), with a diphenylmethyl substituent have been isolated as extremely minor constituents from the root of Securidaca longepedunculata (Polygalaceae). Among them, muchimangin B (2) induced an apoptotic-like cell death of human pancreatic cancer PANC-1 cell line preferentially in nutrient deprived condition with PC50 of 38.9 lM.",

keywords = "Congolese medicinal plant, Pancreatic cancer, Preferential cytotoxicity, Securidaca longepedunculata, Xanthone",

author = "Dibwe, {Dya Fita} and Suresh Awale and Shigetoshi Kadota and Yasuhiro Tezuka",

note = "Funding Information: Parts of this work were supported by a grant from the Ministry of Health and Welfare for the Third Term Comprehensive 10 year Strategy for Cancer Control and a research program of the Project for Development of Innovative Research on Cancer Therapeutics (P-Direct). ",

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doi = "10.1016/j.tetlet.2012.08.115",

language = "英語",

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T1 - Muchimangins A-D

T2 - Novel diphenylmethyl-substituted xanthones from Securidaca longepedunculata

AU - Dibwe, Dya Fita

AU - Awale, Suresh

AU - Kadota, Shigetoshi

AU - Tezuka, Yasuhiro

N1 - Funding Information: Parts of this work were supported by a grant from the Ministry of Health and Welfare for the Third Term Comprehensive 10 year Strategy for Cancer Control and a research program of the Project for Development of Innovative Research on Cancer Therapeutics (P-Direct).

PY - 2012/11/14

Y1 - 2012/11/14

N2 - Four new highly oxygenated xanthones, named muchimangins A-D (1-4), with a diphenylmethyl substituent have been isolated as extremely minor constituents from the root of Securidaca longepedunculata (Polygalaceae). Among them, muchimangin B (2) induced an apoptotic-like cell death of human pancreatic cancer PANC-1 cell line preferentially in nutrient deprived condition with PC50 of 38.9 lM.

AB - Four new highly oxygenated xanthones, named muchimangins A-D (1-4), with a diphenylmethyl substituent have been isolated as extremely minor constituents from the root of Securidaca longepedunculata (Polygalaceae). Among them, muchimangin B (2) induced an apoptotic-like cell death of human pancreatic cancer PANC-1 cell line preferentially in nutrient deprived condition with PC50 of 38.9 lM.

KW - Congolese medicinal plant

KW - Pancreatic cancer

KW - Preferential cytotoxicity

KW - Securidaca longepedunculata

KW - Xanthone

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U2 - 10.1016/j.tetlet.2012.08.115

DO - 10.1016/j.tetlet.2012.08.115

M3 - 学術論文

AN - SCOPUS:84867576263

SN - 0040-4039

VL - 53

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EP - 6190

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 46

ER -

Muchimangins A-D: Novel diphenylmethyl-substituted xanthones from Securidaca longepedunculata

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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