@article{e9d75270b3234535b3823f04fd58171d,
title = "Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase",
abstract = "For the purpose of developing novel anti-hepatitis C virus (HCV) agents from natural resources, 93 Yunnan crude drugs were screened for their inhibitory effects on RNA-dependent RNA polymerase (RdRp) of HCV. Although 71 methanol extracts and 50 water extracts inhibited HCV-RdRp by more than 50% at a concentration of 50 μg/ml, the majority of them contained a high percentage of tannins. However, methanol extracts of Plumbago zeylanica (branch), Maytenus fookerii (leaf) and Huashidancha (Y61, branch and leaf), and water extracts of Potentilla griffithii (whole plant) and Salvia yunnanensis (underground part), having IC50 values of less than 10 μg/ml, showed less than 10% tannin content. In addition, from a methanol extract of Tripterygium hypoglaucum (root bark), demethylzeylasteral was isolated as a strongly inhibitory substance against HCV-RdRp.",
keywords = "Demethylzeylasteral, Hepatitis C virus, RNA-dependent RNA polymerase, Tripterygium hypoglaucum, Yunnan crude drugs",
author = "Michiko Jo and Norio Nakamura and Nobuko Kakiuchi and Katsuko Komatsu and Qui, {Ming Hua} and Kumiko Shimotohno and Kunitada Shimotohno and Masao Hattori",
note = "Funding Information: Medicinal plants (crude drugs) used in this study were collected in Yunnan Province of China in 2000, during the Japan Society for the Promotion of Science (JSPS) Project of Overseas Survey on Ethnical Medicines [12– 15]. The root barks of T. hypoglaucum were obtained from Kunming, Yunnan Province, China, and the botanical source was identified by K.K. These specimens are deposited in the Herbarium of Materia Medica of University of Toyama (TMPW no. 24248, 24249).",
year = "2006",
month = jul,
doi = "10.1007/s11418-006-0041-7",
language = "英語",
volume = "60",
pages = "217--224",
journal = "Natural Medicines",
issn = "1340-3443",
publisher = "Springer Japan",
number = "3",
}
