Influence of acute exposure to a low dose of systemic insecticide fipronil on locomotor activity and emotional behavior in adult male mice

Mizuki Maeda, Toshifumi Yokoyama*, Sayaka Kitauchi, Tetsushi Hirano, Youhei Mantani, Yoshiaki Tabuchi, Nobuhiko Hoshi

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

6 被引用数 (Scopus)

抄録

Fipronil (FPN) is a systemic insecticide that antagonizes the gamma-aminobutyric acid type A (GABAA) receptors in insects. Recently, adverse effects of FPN on mammals have been reported, but most of those were caused by high doses of FPN and additives in the products. We investigated the effects of low-dose pure FPN on the emotional behavior of mice. Nine-week-old male mice conducted behavioral tests 24 hr after FPN administration by gavage at doses of 0.05 or 5 mg/kg based on the no-observed-effect level (NOEL), showed a significant increase in locomotor activity and dose-dependent responses on the time they spent in the central zone in the open field test. Pure FPN below the NOEL dose may affect the emotional behavior of mice.

本文言語英語
ページ(範囲)344-348
ページ数5
ジャーナルJournal of Veterinary Medical Science
83
2
DOI
出版ステータス出版済み - 2021

ASJC Scopus 主題領域

  • 獣医学一般

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