抄録
A human B cell clone (SGB3) responsive to IL 2 was established. Both recombinant IL 2 and B cell differentiation factor (BCDF) induced IgG secretion in SGB3 cells in a dose-dependent manner, but IL 2 did not affect the proliferation of SGB3 cells. FACS analysis showed that SGB3 cells expressed Tac antigen and anti-Tac antibody inhibited IL 2-induced IgG secretion without any inhibitory effect on BCDF-induced IgG secretion. These results showed that IL 2 could directly act on B cells and provide a differentiation signal through IL 2 receptors distinct from BCDF receptors. Physiologic relevance of IL 2 in the antibody response was discussed.
| 本文言語 | 英語 |
|---|---|
| ページ（範囲） | 3104-3107 |
| ページ数 | 4 |
| ジャーナル | Journal of Immunology |
| 巻 | 134 |
| 号 | 5 |
| 出版ステータス | 出版済み - 1985 |
ASJC Scopus 主題領域
- 免疫アレルギー学
- 免疫学