Abstract
A human B cell clone (SGB3) responsive to IL 2 was established. Both recombinant IL 2 and B cell differentiation factor (BCDF) induced IgG secretion in SGB3 cells in a dose-dependent manner, but IL 2 did not affect the proliferation of SGB3 cells. FACS analysis showed that SGB3 cells expressed Tac antigen and anti-Tac antibody inhibited IL 2-induced IgG secretion without any inhibitory effect on BCDF-induced IgG secretion. These results showed that IL 2 could directly act on B cells and provide a differentiation signal through IL 2 receptors distinct from BCDF receptors. Physiologic relevance of IL 2 in the antibody response was discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 3104-3107 |
| Number of pages | 4 |
| Journal | Journal of Immunology |
| Volume | 134 |
| Issue number | 5 |
| State | Published - 1985 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology