@inproceedings{2bc6c4ab6bc64c8b8fa8df2d0fbca033,
title = "In vivo detection of cancer cells with immunoconjugated fluorescent probes by macro zoom microscopy and two-photon microscopy",
abstract = "We developed a near infrared fluorophore-conjugated anti-Carcinoembryonic antigen (CEA) antibody for mice bearing tumor of CEA expressing cells, and demonstrated in vivo optical imaging by macro zoom microscopy. In the result, tumors of CEA-expressing cancer cells were specifically detected in vivo. Furthermore, cancer-specific fluorescence images were acquired at subcellular level in vivo by two-photon microscopy. In preclinical applications, the lymph node micrometastasis was also successfully visualized by two-photon microscopy. These results suggest that two-photon excitation microscopy in combination with an immunoconjugated probe could be widely adapted to cancer detection in clinical settings.",
keywords = "CEA, cancer imaging, fluorescent probe, multiphoton microscopy",
author = "Shigehiro Koga and Yusuke Oshima and Atsuhiko Hikita and Koichi Sato and Motohira Yoshida and Yuji Yamamoto and Tadahiro Iimura and Yuji Watanabe and Takeshi Imamura",
note = "Publisher Copyright: {\textcopyright} 2015 SPIE.; Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VII ; Conference date: 08-02-2015 Through 10-02-2015",
year = "2015",
doi = "10.1117/12.2079092",
language = "英語",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Ramesh Raghavachari and Samuel Achilefu",
booktitle = "Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VII",
}
