TY - JOUR
T1 - Immunostimulating effects of a sulfated galactan from Codium fragile
AU - Lee, Jung Bum
AU - Ohta, Yuko
AU - Hayashi, Kyoko
AU - Hayashi, Toshimitsu
PY - 2010/7/2
Y1 - 2010/7/2
N2 - A pyruvylated sulfated galactan from Codium fragile is a highly ramified polysaccharide consisting of 3-linked, 3,6-linked, and non-reducing terminal D-galactose with pyruvate and sulfate groups; the glycan exerts anti-herpes simplex virus type 2 effects in vitro and in vivo. This particular polysaccharide was found to stimulate the production of nitric oxide by inducing iNOS at the mRNA and protein levels. In addition, the polysaccharide also induced several cytokine mRNA expressions such as IL-1β, IL-6, IL-10 and TNF-α. Therefore it appears that the sulfated galactan might possess the immunostimulating effects via activation of macrophages.
AB - A pyruvylated sulfated galactan from Codium fragile is a highly ramified polysaccharide consisting of 3-linked, 3,6-linked, and non-reducing terminal D-galactose with pyruvate and sulfate groups; the glycan exerts anti-herpes simplex virus type 2 effects in vitro and in vivo. This particular polysaccharide was found to stimulate the production of nitric oxide by inducing iNOS at the mRNA and protein levels. In addition, the polysaccharide also induced several cytokine mRNA expressions such as IL-1β, IL-6, IL-10 and TNF-α. Therefore it appears that the sulfated galactan might possess the immunostimulating effects via activation of macrophages.
KW - Codium fragile
KW - Immunostimulating effect
KW - Pyruvylated sulfated galactan
KW - RAW 264.7 cells
UR - http://www.scopus.com/inward/record.url?scp=77955727373&partnerID=8YFLogxK
U2 - 10.1016/j.carres.2010.02.026
DO - 10.1016/j.carres.2010.02.026
M3 - 学術論文
C2 - 20362278
AN - SCOPUS:77955727373
SN - 0008-6215
VL - 345
SP - 1452
EP - 1454
JO - Carbohydrate Research
JF - Carbohydrate Research
IS - 10
ER -