Immunostimulating effects of a sulfated galactan from Codium fragile

Jung Bum Lee*, Yuko Ohta, Kyoko Hayashi, Toshimitsu Hayashi

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

80 被引用数 (Scopus)

抄録

A pyruvylated sulfated galactan from Codium fragile is a highly ramified polysaccharide consisting of 3-linked, 3,6-linked, and non-reducing terminal D-galactose with pyruvate and sulfate groups; the glycan exerts anti-herpes simplex virus type 2 effects in vitro and in vivo. This particular polysaccharide was found to stimulate the production of nitric oxide by inducing iNOS at the mRNA and protein levels. In addition, the polysaccharide also induced several cytokine mRNA expressions such as IL-1β, IL-6, IL-10 and TNF-α. Therefore it appears that the sulfated galactan might possess the immunostimulating effects via activation of macrophages.

本文言語英語
ページ(範囲)1452-1454
ページ数3
ジャーナルCarbohydrate Research
345
10
DOI
出版ステータス出版済み - 2010/07/02

ASJC Scopus 主題領域

  • 分析化学
  • 生化学
  • 有機化学

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