Immunostimulating effects of a sulfated galactan from Codium fragile

Jung Bum Lee; Yuko Ohta; Kyoko Hayashi; Toshimitsu Hayashi

doi:10.1016/j.carres.2010.02.026

Immunostimulating effects of a sulfated galactan from Codium fragile

Jung Bum Lee^*, Yuko Ohta, Kyoko Hayashi, Toshimitsu Hayashi

^*Corresponding author for this work

Plant Resource Sciences

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

A pyruvylated sulfated galactan from Codium fragile is a highly ramified polysaccharide consisting of 3-linked, 3,6-linked, and non-reducing terminal D-galactose with pyruvate and sulfate groups; the glycan exerts anti-herpes simplex virus type 2 effects in vitro and in vivo. This particular polysaccharide was found to stimulate the production of nitric oxide by inducing iNOS at the mRNA and protein levels. In addition, the polysaccharide also induced several cytokine mRNA expressions such as IL-1β, IL-6, IL-10 and TNF-α. Therefore it appears that the sulfated galactan might possess the immunostimulating effects via activation of macrophages.

Original language	English
Pages (from-to)	1452-1454
Number of pages	3
Journal	Carbohydrate Research
Volume	345
Issue number	10
DOIs	https://doi.org/10.1016/j.carres.2010.02.026
State	Published - 2010/07/02

Keywords

Codium fragile
Immunostimulating effect
Pyruvylated sulfated galactan
RAW 264.7 cells

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Organic Chemistry

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10.1016/j.carres.2010.02.026

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title = "Immunostimulating effects of a sulfated galactan from Codium fragile",

abstract = "A pyruvylated sulfated galactan from Codium fragile is a highly ramified polysaccharide consisting of 3-linked, 3,6-linked, and non-reducing terminal D-galactose with pyruvate and sulfate groups; the glycan exerts anti-herpes simplex virus type 2 effects in vitro and in vivo. This particular polysaccharide was found to stimulate the production of nitric oxide by inducing iNOS at the mRNA and protein levels. In addition, the polysaccharide also induced several cytokine mRNA expressions such as IL-1β, IL-6, IL-10 and TNF-α. Therefore it appears that the sulfated galactan might possess the immunostimulating effects via activation of macrophages.",

keywords = "Codium fragile, Immunostimulating effect, Pyruvylated sulfated galactan, RAW 264.7 cells",

author = "Lee, {Jung Bum} and Yuko Ohta and Kyoko Hayashi and Toshimitsu Hayashi",

year = "2010",

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T1 - Immunostimulating effects of a sulfated galactan from Codium fragile

AU - Lee, Jung Bum

AU - Ohta, Yuko

AU - Hayashi, Kyoko

AU - Hayashi, Toshimitsu

PY - 2010/7/2

Y1 - 2010/7/2

N2 - A pyruvylated sulfated galactan from Codium fragile is a highly ramified polysaccharide consisting of 3-linked, 3,6-linked, and non-reducing terminal D-galactose with pyruvate and sulfate groups; the glycan exerts anti-herpes simplex virus type 2 effects in vitro and in vivo. This particular polysaccharide was found to stimulate the production of nitric oxide by inducing iNOS at the mRNA and protein levels. In addition, the polysaccharide also induced several cytokine mRNA expressions such as IL-1β, IL-6, IL-10 and TNF-α. Therefore it appears that the sulfated galactan might possess the immunostimulating effects via activation of macrophages.

AB - A pyruvylated sulfated galactan from Codium fragile is a highly ramified polysaccharide consisting of 3-linked, 3,6-linked, and non-reducing terminal D-galactose with pyruvate and sulfate groups; the glycan exerts anti-herpes simplex virus type 2 effects in vitro and in vivo. This particular polysaccharide was found to stimulate the production of nitric oxide by inducing iNOS at the mRNA and protein levels. In addition, the polysaccharide also induced several cytokine mRNA expressions such as IL-1β, IL-6, IL-10 and TNF-α. Therefore it appears that the sulfated galactan might possess the immunostimulating effects via activation of macrophages.

KW - Codium fragile

KW - Immunostimulating effect

KW - Pyruvylated sulfated galactan

KW - RAW 264.7 cells

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JO - Carbohydrate Research

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Immunostimulating effects of a sulfated galactan from Codium fragile

Abstract

Keywords

ASJC Scopus subject areas

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