Hernandezine promotes cancer cell apoptosis and disrupts the lysosomal acidic environment and cathepsin D maturation

Biochemistry, Genetics and Molecular Biology

• Cancer Cell 100%
• Autophagy 100%
• Maturation 100%
• Cathepsin D 100%
• Cell Death 60%
• Autophagosome 60%
• Necroptosis 40%
• Mitophagy 40%
• Upregulation 20%
• Lysosome 20%
• Biological Activity 20%
• AMP-activated Protein Kinase 20%
• Mitochondrion 20%
• Cytotoxicity 20%
• Apoptosis 20%
• Outer Mitochondrial Membrane 20%
• Bafilomycin 20%
• Mitochondrial Membrane 20%
• ATG5 20%
• ATG16L1 20%
• Thalictrum 20%

Keyphrases

• Cell Apoptosis 100%
• Acidic Environment 100%
• Cathepsin D 100%
• Hernandezine 100%
• Apoptosis 16%
• Autophagy 16%
• Selective Autophagy 16%
• Autophagosome 16%
• Necroptosis 16%
• Programmed Cell Death 16%
• Mitophagy 16%
• LC3-II 16%
• Autophagosome Formation 16%
• Cancer Cells 8%
• Conjugated System 8%
• In Cancer 8%
• Lysosome 8%
• Protective Behavior 8%
• Induced Cell Death 8%
• Apoptotic Cell Death 8%
• Biological Activity 8%
• Autophagic 8%
• Anticancer Effect 8%
• Cytotoxicity 8%
• Herbal Medicine 8%
• Lysosomal Function 8%
• Bafilomycin A1 8%
• Autophagic Flux 8%
• Reporter Assay 8%
• Dual Role 8%
• Mitochondrial Damage 8%
• Autophagy Inhibitor 8%
• 3-methyladenine (3-MA) 8%
• LC3 Lipidation 8%
• Cancer Prevention Strategies 8%
• Thalictrum 8%
• Flavon 8%
• Lysosomal pH 8%
• ATG5 8%
• Cancer Therapeutic Strategy 8%
• GFP-LC3 8%
• Mitochondria-associated Membranes 8%
• Benzylisoquinoline Alkaloids 8%
• ATG16L1 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Malignant Neoplasm 100%
• Hernandesine 100%
• Cathepsin D 100%
• Programmed Cell Death 16%
• Biological Activity 8%
• Bafilomycin A1 8%
• Thalictrum 8%
• Bisbenzylisoquinoline Alkaloid 8%
• 3 Methyladenine 8%
• Cytotoxicity 8%