Helodermin has a VIP-like effect upon canine blood flow

S. Naruse, A. Yasui, S. Kishida, M. Kadowaki, M. Hoshino, T. Ozaki, P. Robberecht, J. Christophe, C. Yanaihara, N. Yanaihara*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

26 被引用数 (Scopus)

抄録

The effect of helodermin on vascular physiology was studied in anesthetized dogs using a synthetic replicate of helodermin and helodermin related peptides. Intraarterial infusion of helodermin caused a dosedependent increase in femoral blood flow. Helodermin was 16 times less potent than VIP and 5 times more potent than PHM (human PHI). The helodermin effect lasted significantly longer; the half-life of the helodermin effect was 6.5 times longer than VIP. Synthetic helodermin (Hd) N-terminal fragment Hd(1-27)NH2 retained substantial activity similar to the full helodermin molecule but the prolonged effect was lost. Hd(7-35) and Hd(22-35) were inactive in this system. Intravenous injection of synthetic helodermin produced prolonged systemic hypotension and tachycardia; and, similar to VIP, it increased the common carotid arterial blood flow while those of the superior mesenteric and femoral arteries were decreased. The results demonstrate the VIP-like vasodilating activity and cardiovascular effects of helodermin in anesthetized dogs.

本文言語英語
ページ(範囲)237-240
ページ数4
ジャーナルPeptides
7
SUPPL. 1
DOI
出版ステータス出版済み - 1986

ASJC Scopus 主題領域

  • 生化学
  • 生理学
  • 内分泌学
  • 細胞および分子神経科学

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