Helodermin has a VIP-like effect upon canine blood flow

S. Naruse, A. Yasui, S. Kishida, M. Kadowaki, M. Hoshino, T. Ozaki, P. Robberecht, J. Christophe, C. Yanaihara, N. Yanaihara*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The effect of helodermin on vascular physiology was studied in anesthetized dogs using a synthetic replicate of helodermin and helodermin related peptides. Intraarterial infusion of helodermin caused a dosedependent increase in femoral blood flow. Helodermin was 16 times less potent than VIP and 5 times more potent than PHM (human PHI). The helodermin effect lasted significantly longer; the half-life of the helodermin effect was 6.5 times longer than VIP. Synthetic helodermin (Hd) N-terminal fragment Hd(1-27)NH2 retained substantial activity similar to the full helodermin molecule but the prolonged effect was lost. Hd(7-35) and Hd(22-35) were inactive in this system. Intravenous injection of synthetic helodermin produced prolonged systemic hypotension and tachycardia; and, similar to VIP, it increased the common carotid arterial blood flow while those of the superior mesenteric and femoral arteries were decreased. The results demonstrate the VIP-like vasodilating activity and cardiovascular effects of helodermin in anesthetized dogs.

Original languageEnglish
Pages (from-to)237-240
Number of pages4
JournalPeptides
Volume7
Issue numberSUPPL. 1
DOIs
StatePublished - 1986

Keywords

  • Femoral blood flow
  • Helodermin
  • Peptide histidine isoleucine/methionine (PHI/PHM)
  • Structure-function relationship
  • Vasoactive intestinal polypeptide (VIP)

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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