Growth inhibitory activity of wood of Taxus yunnanensis and its liquid chromatography fourier-transform mass spectrometry analysis

Jun Ya Ueda; Suresh Awale; Yasuhiro Tezuka; Eriko Shimamura; Kei Ichi Hirai; Takahiro Nobukawa; Akihiro Sato; Shigetoshi Kadota

doi:10.1055/s-2006-947197

Growth inhibitory activity of wood of Taxus yunnanensis and its liquid chromatography fourier-transform mass spectrometry analysis

Jun Ya Ueda, Suresh Awale, Yasuhiro Tezuka, Eriko Shimamura, Kei Ichi Hirai, Takahiro Nobukawa, Akihiro Sato, Shigetoshi Kadota^*

^*この論文の責任著者

和漢医薬学総合研究所研究開発部門資源開発分野（天然物創薬学領域）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

4 被引用数 (Scopus)

抄録

The wood of Taxus yunnanensis (Taxaceae) showed growth inhibitory activities against human cancer cell lines, such as cervical HeLa adenocarcinoma. The morphological changes indicated that the cellular growth inhibitions were caused by apoptosis. To determine the active components, T. yunnanensis wood was analyzed by using a liquid chromatography-Fourier-transform MS (LC/FT-MS) technique. As a result, taxane-type diterpenes, such as 10-deacetylcephalomannine and 10-deacetyltaxol, were found to be present in amounts consistent with the growth inhibitory activity.

本文言語	英語
ページ（範囲）	1241-1244
ページ数	4
ジャーナル	Planta Medica
巻	72
号	13
DOI	https://doi.org/10.1055/s-2006-947197
出版ステータス	出版済み - 2006/10

ASJC Scopus 主題領域

分析化学
分子医療
薬理学
薬科学
創薬
補完代替医療
有機化学

文献へのアクセス

10.1055/s-2006-947197

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引用スタイル

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abstract = "The wood of Taxus yunnanensis (Taxaceae) showed growth inhibitory activities against human cancer cell lines, such as cervical HeLa adenocarcinoma. The morphological changes indicated that the cellular growth inhibitions were caused by apoptosis. To determine the active components, T. yunnanensis wood was analyzed by using a liquid chromatography-Fourier-transform MS (LC/FT-MS) technique. As a result, taxane-type diterpenes, such as 10-deacetylcephalomannine and 10-deacetyltaxol, were found to be present in amounts consistent with the growth inhibitory activity.",

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AU - Ueda, Jun Ya

AU - Awale, Suresh

AU - Tezuka, Yasuhiro

AU - Shimamura, Eriko

AU - Hirai, Kei Ichi

AU - Nobukawa, Takahiro

AU - Sato, Akihiro

AU - Kadota, Shigetoshi

PY - 2006/10

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AB - The wood of Taxus yunnanensis (Taxaceae) showed growth inhibitory activities against human cancer cell lines, such as cervical HeLa adenocarcinoma. The morphological changes indicated that the cellular growth inhibitions were caused by apoptosis. To determine the active components, T. yunnanensis wood was analyzed by using a liquid chromatography-Fourier-transform MS (LC/FT-MS) technique. As a result, taxane-type diterpenes, such as 10-deacetylcephalomannine and 10-deacetyltaxol, were found to be present in amounts consistent with the growth inhibitory activity.

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