Growth inhibitory activity of wood of Taxus yunnanensis and its liquid chromatography fourier-transform mass spectrometry analysis

Jun Ya Ueda; Suresh Awale; Yasuhiro Tezuka; Eriko Shimamura; Kei Ichi Hirai; Takahiro Nobukawa; Akihiro Sato; Shigetoshi Kadota

doi:10.1055/s-2006-947197

Growth inhibitory activity of wood of Taxus yunnanensis and its liquid chromatography fourier-transform mass spectrometry analysis

Jun Ya Ueda, Suresh Awale, Yasuhiro Tezuka, Eriko Shimamura, Kei Ichi Hirai, Takahiro Nobukawa, Akihiro Sato, Shigetoshi Kadota^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The wood of Taxus yunnanensis (Taxaceae) showed growth inhibitory activities against human cancer cell lines, such as cervical HeLa adenocarcinoma. The morphological changes indicated that the cellular growth inhibitions were caused by apoptosis. To determine the active components, T. yunnanensis wood was analyzed by using a liquid chromatography-Fourier-transform MS (LC/FT-MS) technique. As a result, taxane-type diterpenes, such as 10-deacetylcephalomannine and 10-deacetyltaxol, were found to be present in amounts consistent with the growth inhibitory activity.

Original language	English
Pages (from-to)	1241-1244
Number of pages	4
Journal	Planta Medica
Volume	72
Issue number	13
DOIs	https://doi.org/10.1055/s-2006-947197
State	Published - 2006/10

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Growth inhibitory activity of wood of Taxus yunnanensis and its liquid chromatography fourier-transform mass spectrometry analysis",

abstract = "The wood of Taxus yunnanensis (Taxaceae) showed growth inhibitory activities against human cancer cell lines, such as cervical HeLa adenocarcinoma. The morphological changes indicated that the cellular growth inhibitions were caused by apoptosis. To determine the active components, T. yunnanensis wood was analyzed by using a liquid chromatography-Fourier-transform MS (LC/FT-MS) technique. As a result, taxane-type diterpenes, such as 10-deacetylcephalomannine and 10-deacetyltaxol, were found to be present in amounts consistent with the growth inhibitory activity.",

author = "Ueda, {Jun Ya} and Suresh Awale and Yasuhiro Tezuka and Eriko Shimamura and Hirai, {Kei Ichi} and Takahiro Nobukawa and Akihiro Sato and Shigetoshi Kadota",

year = "2006",

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doi = "10.1055/s-2006-947197",

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T1 - Growth inhibitory activity of wood of Taxus yunnanensis and its liquid chromatography fourier-transform mass spectrometry analysis

AU - Ueda, Jun Ya

AU - Awale, Suresh

AU - Tezuka, Yasuhiro

AU - Shimamura, Eriko

AU - Hirai, Kei Ichi

AU - Nobukawa, Takahiro

AU - Sato, Akihiro

AU - Kadota, Shigetoshi

PY - 2006/10

Y1 - 2006/10

N2 - The wood of Taxus yunnanensis (Taxaceae) showed growth inhibitory activities against human cancer cell lines, such as cervical HeLa adenocarcinoma. The morphological changes indicated that the cellular growth inhibitions were caused by apoptosis. To determine the active components, T. yunnanensis wood was analyzed by using a liquid chromatography-Fourier-transform MS (LC/FT-MS) technique. As a result, taxane-type diterpenes, such as 10-deacetylcephalomannine and 10-deacetyltaxol, were found to be present in amounts consistent with the growth inhibitory activity.

AB - The wood of Taxus yunnanensis (Taxaceae) showed growth inhibitory activities against human cancer cell lines, such as cervical HeLa adenocarcinoma. The morphological changes indicated that the cellular growth inhibitions were caused by apoptosis. To determine the active components, T. yunnanensis wood was analyzed by using a liquid chromatography-Fourier-transform MS (LC/FT-MS) technique. As a result, taxane-type diterpenes, such as 10-deacetylcephalomannine and 10-deacetyltaxol, were found to be present in amounts consistent with the growth inhibitory activity.

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DO - 10.1055/s-2006-947197

M3 - 学術論文

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AN - SCOPUS:33751041713

SN - 0032-0943

VL - 72

SP - 1241

EP - 1244

JO - Planta Medica

JF - Planta Medica

IS - 13

ER -

Growth inhibitory activity of wood of Taxus yunnanensis and its liquid chromatography fourier-transform mass spectrometry analysis

Abstract

ASJC Scopus subject areas

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