Genetic differences between c57bl/6 substrains affect the process of testis differentiation in y pos mice

Toshifumi Yokoyama*, Yuuka Miura, Anzu Yamamoto, Chinatsu Hasegawa, Kohei Kawanishi, Nanako Takada, Takuya Omotehara, Tetsushi Hirano, Yohei Mantani, Takanori Miki, Nobuhiko Hoshi

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

3 被引用数 (Scopus)

抄録

C57BL/6J-XY POS (B6J-XY POS ) mice, which have the Y chromosome derived from Mus musculus poschiavinus on a B6J genetic background, form ovotestes or ovaries. Previously, we replaced the genetic background of B6J-XY POS mice with B6N and found that individuals with testes also appeared in addition to those with ovaries or ovotestes. To investigate the effect of the B6J genetic sequence on the testis differentiation, the genetic background of B6N-XY POS mice was replaced with B6J again. The recovery of the B6J genetic background significantly decreased the incidence of testes; only ovaries developed. These results indicate that the testicular differentiation process tends to be perturbed especially in the B6J substrain. This shows the importance of substrain differences in mice usually treated as B6 collectively.

本文言語英語
ページ(範囲)608-611
ページ数4
ジャーナルJournal of Veterinary Medical Science
81
4
DOI
出版ステータス出版済み - 2019

ASJC Scopus 主題領域

  • 獣医学一般

フィンガープリント

「Genetic differences between c57bl/6 substrains affect the process of testis differentiation in y pos mice」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル