Genetic differences between c57bl/6 substrains affect the process of testis differentiation in y                         pos                          mice

Toshifumi Yokoyama; Yuuka Miura; Anzu Yamamoto; Chinatsu Hasegawa; Kohei Kawanishi; Nanako Takada; Takuya Omotehara; Tetsushi Hirano; Yohei Mantani; Takanori Miki; Nobuhiko Hoshi

doi:10.1292/jvms.18-0621

Genetic differences between c57bl/6 substrains affect the process of testis differentiation in y ^pos mice

Toshifumi Yokoyama^*, Yuuka Miura, Anzu Yamamoto, Chinatsu Hasegawa, Kohei Kawanishi, Nanako Takada, Takuya Omotehara, Tetsushi Hirano, Yohei Mantani, Takanori Miki, Nobuhiko Hoshi

^*Corresponding author for this work

Division of Drug and Structural Research, Life Science Research Center, Organization for Promotion of Research

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

C57BL/6J-XY ^POS (B6J-XY ^POS ) mice, which have the Y chromosome derived from Mus musculus poschiavinus on a B6J genetic background, form ovotestes or ovaries. Previously, we replaced the genetic background of B6J-XY ^POS mice with B6N and found that individuals with testes also appeared in addition to those with ovaries or ovotestes. To investigate the effect of the B6J genetic sequence on the testis differentiation, the genetic background of B6N-XY ^POS mice was replaced with B6J again. The recovery of the B6J genetic background significantly decreased the incidence of testes; only ovaries developed. These results indicate that the testicular differentiation process tends to be perturbed especially in the B6J substrain. This shows the importance of substrain differences in mice usually treated as B6 collectively.

Original language	English
Pages (from-to)	608-611
Number of pages	4
Journal	Journal of Veterinary Medical Science
Volume	81
Issue number	4
DOIs	https://doi.org/10.1292/jvms.18-0621
State	Published - 2019

Keywords

C57BL/6
Mus musculus poschiavinus
Sex reversal
Substrain
Testis differentiatio

ASJC Scopus subject areas

General Veterinary

Access to Document

10.1292/jvms.18-0621

Cite this

Yokoyama, T., Miura, Y., Yamamoto, A., Hasegawa, C., Kawanishi, K., Takada, N., Omotehara, T., Hirano, T., Mantani, Y., Miki, T., & Hoshi, N. (2019). Genetic differences between c57bl/6 substrains affect the process of testis differentiation in y ^pos mice. Journal of Veterinary Medical Science, 81(4), 608-611. https://doi.org/10.1292/jvms.18-0621

@article{44ca580174554a94a3046c1256c6acc7,

title = "Genetic differences between c57bl/6 substrains affect the process of testis differentiation in y pos mice",

abstract = " C57BL/6J-XY POS (B6J-XY POS ) mice, which have the Y chromosome derived from Mus musculus poschiavinus on a B6J genetic background, form ovotestes or ovaries. Previously, we replaced the genetic background of B6J-XY POS mice with B6N and found that individuals with testes also appeared in addition to those with ovaries or ovotestes. To investigate the effect of the B6J genetic sequence on the testis differentiation, the genetic background of B6N-XY POS mice was replaced with B6J again. The recovery of the B6J genetic background significantly decreased the incidence of testes; only ovaries developed. These results indicate that the testicular differentiation process tends to be perturbed especially in the B6J substrain. This shows the importance of substrain differences in mice usually treated as B6 collectively.",

keywords = "C57BL/6, Mus musculus poschiavinus, Sex reversal, Substrain, Testis differentiatio",

author = "Toshifumi Yokoyama and Yuuka Miura and Anzu Yamamoto and Chinatsu Hasegawa and Kohei Kawanishi and Nanako Takada and Takuya Omotehara and Tetsushi Hirano and Yohei Mantani and Takanori Miki and Nobuhiko Hoshi",

note = "Publisher Copyright: {\textcopyright} 2019 The Japanese Society of Veterinary Science.",

year = "2019",

doi = "10.1292/jvms.18-0621",

language = "英語",

volume = "81",

pages = "608--611",

journal = "Journal of Veterinary Medical Science",

issn = "0916-7250",

publisher = "Japanese Society of Veterinary Science",

number = "4",

}

Yokoyama, T, Miura, Y, Yamamoto, A, Hasegawa, C, Kawanishi, K, Takada, N, Omotehara, T, Hirano, T, Mantani, Y, Miki, T & Hoshi, N 2019, 'Genetic differences between c57bl/6 substrains affect the process of testis differentiation in y ^pos mice', Journal of Veterinary Medical Science, vol. 81, no. 4, pp. 608-611. https://doi.org/10.1292/jvms.18-0621

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T1 - Genetic differences between c57bl/6 substrains affect the process of testis differentiation in y pos mice

AU - Yokoyama, Toshifumi

AU - Miura, Yuuka

AU - Yamamoto, Anzu

AU - Hasegawa, Chinatsu

AU - Kawanishi, Kohei

AU - Takada, Nanako

AU - Omotehara, Takuya

AU - Hirano, Tetsushi

AU - Mantani, Yohei

AU - Miki, Takanori

AU - Hoshi, Nobuhiko

PY - 2019

Y1 - 2019

N2 - C57BL/6J-XY POS (B6J-XY POS ) mice, which have the Y chromosome derived from Mus musculus poschiavinus on a B6J genetic background, form ovotestes or ovaries. Previously, we replaced the genetic background of B6J-XY POS mice with B6N and found that individuals with testes also appeared in addition to those with ovaries or ovotestes. To investigate the effect of the B6J genetic sequence on the testis differentiation, the genetic background of B6N-XY POS mice was replaced with B6J again. The recovery of the B6J genetic background significantly decreased the incidence of testes; only ovaries developed. These results indicate that the testicular differentiation process tends to be perturbed especially in the B6J substrain. This shows the importance of substrain differences in mice usually treated as B6 collectively.

AB - C57BL/6J-XY POS (B6J-XY POS ) mice, which have the Y chromosome derived from Mus musculus poschiavinus on a B6J genetic background, form ovotestes or ovaries. Previously, we replaced the genetic background of B6J-XY POS mice with B6N and found that individuals with testes also appeared in addition to those with ovaries or ovotestes. To investigate the effect of the B6J genetic sequence on the testis differentiation, the genetic background of B6N-XY POS mice was replaced with B6J again. The recovery of the B6J genetic background significantly decreased the incidence of testes; only ovaries developed. These results indicate that the testicular differentiation process tends to be perturbed especially in the B6J substrain. This shows the importance of substrain differences in mice usually treated as B6 collectively.

KW - C57BL/6

KW - Mus musculus poschiavinus

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KW - Substrain

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