Fetal and lactational exposure to the no-observed-adverse-effect level (Noael) dose of the neonicotinoid pesticide clothianidin inhibits neurogenesis and induces different behavioral abnormalities at the developmental stages in male mice

Mizuki Maeda, Sayaka Kitauchi, Tetsushi Hirano, Yoshinori Ikenaka, Misaki Nishi, Asuka Shoda, Midori Murata, Youhei Mantani, Yoshiaki Tabuchi, Toshifumi Yokoyama, Nobuhiko Hoshi*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

20 被引用数 (Scopus)

抄録

Recently, it has been reported that neonicotinoid pesticides (NNs) are transferred from mother to child and are assumed to affect the next generation, but the behavioral effects of NN exposure at different developmental stages have not been investigated. We exposed mice to no-observed-adverse-effect level (NOAEL) doses of clothianidin (CLO) during the fetal and lactational period, and then evaluated the neurobehavioral effects in juvenile and adult mice. Significant increases in anxiety-like behavior and locomotor activity were observed in juveniles and adults, respectively, and neuronal activity and neurogenesis in the hippocampal dentate gyrus were affected in both stages. These results suggest that fetal and lactational exposure to CLO may inhibit neurogenesis and cause different behavioral abnormalities at different developmental stages.

本文言語英語
ページ(範囲)542-548
ページ数7
ジャーナルJournal of Veterinary Medical Science
83
3
DOI
出版ステータス出版済み - 2021

ASJC Scopus 主題領域

  • 獣医学一般

フィンガープリント

「Fetal and lactational exposure to the no-observed-adverse-effect level (Noael) dose of the neonicotinoid pesticide clothianidin inhibits neurogenesis and induces different behavioral abnormalities at the developmental stages in male mice」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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