Evaluation of phenytoin dosage regimens based on genotyping of CYP2C subfamily in routinely treated Japanese patients.

Keyphrases

• Japanese Patients 100%
• Phenytoin 100%
• CYP2C 100%
• Dosage Regimen 100%
• Genotype 28%
• Pharmacokinetic Parameters 28%
• Inter-individual Variability 28%
• Vmax 28%
• Steady State 14%
• Plasma Concentration 14%
• Genetic Polymorphism 14%
• Plasma Protein Binding 14%
• Metabolic Activity 14%
• Population Estimate 14%
• CYP2C9 14%
• CYP2C19 14%
• Bayes Theorem 14%
• Epileptic Patients 14%
• Unbound Fraction 14%

Biochemistry, Genetics and Molecular Biology

• Genotyping 100%
• Drug Dose Regimen 100%
• Pharmacokinetics 50%
• Blood Plasma 50%
• Blood Level 25%
• Genetic Polymorphism 25%
• CYP2C19 25%
• CYP2C9 25%
• Concentration at Steady-State 25%
• Plasma Protein Binding 25%
• Intrinsic Clearance 25%
• Maximum Reaction Velocity 25%

Immunology and Microbiology

• Drug Dose Regimen 100%
• Blood Plasma 66%
• Pharmacokinetics 66%
• Blood Level 33%
• Plasma Protein Binding 33%
• Genetic Polymorphism 33%
• Concentration at Steady-State 33%
• Maximum Reaction Velocity 33%
• Intrinsic Clearance 33%