@inproceedings{039d41094375494d8bbd3f27d84e11f6,
title = "Endogenous pituitary adenylate cyclase activating polypeptide is involved in suppression of edema in the ischemic brain",
abstract = "Pituitary adenylate cyclase activating polypeptide is a pleiotropic neuropeptide. We previously showed that heterozygous PACAP gene knockout (PACAP+/-) mice had larger infarct volumes and worse neurological scores after middle cerebral artery occlusion (MCAO). However, the relationship between endogenous PACAP levels and edema in the ischemic brain has not yet been evaluated. In this study, the formation of edema in the ischemic brain as well as cerebral blood flow was compared between PACAP+/- and wild-type (PACAP+/+) mice. The amount of brain edema was calculated by subtracting the contralateral volume from the ipsilateral volume 24 h after permanent MCAO. PACAP+/- mice showed significantly greater brain edema than PACAP+/+ mice. To investigate the effects of endogenous PACAP on blood flow during ischemia, cerebral blood flow in the ipsilateral and the contralateral cortices was compared between PACAP+/- and PACAP+/+ mice for 25 min after ischemia. With a two-dimensional laser Doppler perfusion imaging system, the blood flow in the ipsilateral and contralateral cortices was shown to be similar in PACAP+/- and PACAP+/+ mice during ischemia. These results suggest that endogenous PACAP suppresses the formation of edema in the ischemic brain.",
keywords = "PACAP, brain edema, cerebral blood flow, knockout, mouse, neural peptides, stroke",
author = "Tomoya Nakamachi and Hirokazu Ohtaki and Sachiko Yofu and Kenji Dohi and Jun Watanabe and Hiroyoshi Mori and Atsushi Sato and Hitoshi Hashimoto and Norihito Shintani and Akemichi Baba and Seiji Shioda",
note = "Funding Information: We thank Dr. Jerome L. Maderdrut (Tulane University) for his editorial assistance. This work was supported in part by a Showa University Grant-in-Aid for Innovative Collaborative Research Projects and a Special Research Grant-in-Aid for Development of Characteristic Education from the Ministry of Education, Culture, Sports, Science, and Technology (T.N. and S.S.) and Research on Health Sciences focusing on Drug Innovation from The Japan Health Sciences Foundation (S.S).",
year = "2009",
doi = "10.1007/978-3-211-98811-4_6",
language = "英語",
isbn = "9783211987582",
series = "Acta Neurochirurgica, Supplementum",
publisher = "Springer-Verlag Wien",
number = "106",
pages = "43--46",
booktitle = "Brain Edema XIV",
edition = "106",
}