Effects of in utero and lactational exposure to the no-observed-adverse-effect level (Noael) dose of the neonicotinoid clothianidin on the reproductive organs of female mice

Sayaka Kitauchi, Mizuki Maeda, Tetsushi Hirano, Yoshinori Ikenaka, Misaki Nishi, Asuka Shoda, Midori Murata, Youhei Mantani, Toshifumi Yokoyama, Yoshiaki Tabuchi, Nobuhiko Hoshi*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

19 被引用数 (Scopus)

抄録

Recently, developmental exposure to clothianidin (CLO) has been shown to cause reproductive toxicity in male mice, but the effects in female mice remain to be clarified. Pregnant C57BL/6N mice were given a no-observed-adverse-effect-level (NOAEL) dose of CLO until weaning. We then examined ovaries of 3-or 10-week-old female offspring. In the CLO-administered group, morphological changes, a decrease in the immunoreactivity of the antioxidant enzyme glutathione peroxidase 4 (GPx4), and activation of genes in the steroid hormone biosynthesis pathway were observed in 3-week-old mice, and decreases of GPx4 immunoreactivity, 17OH-progesterone and corticosterone levels were observed in 10-week-old mice, along with high rates of infanticide and severe neglect, providing new evidence that developmental exposure to CLO affects juvenile and adult mice differently.

本文言語英語
ページ(範囲)746-753
ページ数8
ジャーナルJournal of Veterinary Medical Science
83
4
DOI
出版ステータス出版済み - 2021

ASJC Scopus 主題領域

  • 獣医学一般

フィンガープリント

「Effects of in utero and lactational exposure to the no-observed-adverse-effect level (Noael) dose of the neonicotinoid clothianidin on the reproductive organs of female mice」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル