抄録
Rats were fed diets with three different ratios of α-linolenate (18:3 n-3) and linoleate (18:2 n-6), and then crescentic-type anti-glomerular basement membrane (GBM) nephritis was induced. The urinary protein levels and the plasma urea nitrogen levels were significantly higher, and histological abnormalities of glomeruli were seen more frequently in the high-α-linolenate group than in the high-linoleate group. The differences in dietary α-linolenate/linoleate balances were reflected in the proportions of arachidonate and eicosapentaenoate in glomerular phospholipids. Our results indicate that dietary enrichment with α-linolenate causes unfavorable effects in this anti-GBM nephritis model.
| 本文言語 | 英語 |
|---|---|
| ページ（範囲） | 267-272 |
| ページ数 | 6 |
| ジャーナル | Lipids |
| 巻 | 25 |
| 号 | 5 |
| DOI | |
| 出版ステータス | 出版済み - 1990/05 |
ASJC Scopus 主題領域
- 生化学
- 有機化学
- 細胞生物学