Effect of dietary α-linolenate/linoleate balance on crescent type-anti-glomerular basement membrane nephritis in rats

Shiro Watanabe; Erika Suzuki; Ryoji Kojima; Yoshio Suzuki; Harumi Okuyama

doi:10.1007/BF02544386

Effect of dietary α-linolenate/linoleate balance on crescent type-anti-glomerular basement membrane nephritis in rats

Shiro Watanabe, Erika Suzuki, Ryoji Kojima, Yoshio Suzuki, Harumi Okuyama^*

^*Corresponding author for this work

Section of Host Defences, Division of Bioscience, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Rats were fed diets with three different ratios of α-linolenate (18:3 n-3) and linoleate (18:2 n-6), and then crescentic-type anti-glomerular basement membrane (GBM) nephritis was induced. The urinary protein levels and the plasma urea nitrogen levels were significantly higher, and histological abnormalities of glomeruli were seen more frequently in the high-α-linolenate group than in the high-linoleate group. The differences in dietary α-linolenate/linoleate balances were reflected in the proportions of arachidonate and eicosapentaenoate in glomerular phospholipids. Our results indicate that dietary enrichment with α-linolenate causes unfavorable effects in this anti-GBM nephritis model.

Original language	English
Pages (from-to)	267-272
Number of pages	6
Journal	Lipids
Volume	25
Issue number	5
DOIs	https://doi.org/10.1007/BF02544386
State	Published - 1990/05

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Cell Biology

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title = "Effect of dietary α-linolenate/linoleate balance on crescent type-anti-glomerular basement membrane nephritis in rats",

abstract = "Rats were fed diets with three different ratios of α-linolenate (18:3 n-3) and linoleate (18:2 n-6), and then crescentic-type anti-glomerular basement membrane (GBM) nephritis was induced. The urinary protein levels and the plasma urea nitrogen levels were significantly higher, and histological abnormalities of glomeruli were seen more frequently in the high-α-linolenate group than in the high-linoleate group. The differences in dietary α-linolenate/linoleate balances were reflected in the proportions of arachidonate and eicosapentaenoate in glomerular phospholipids. Our results indicate that dietary enrichment with α-linolenate causes unfavorable effects in this anti-GBM nephritis model.",

author = "Shiro Watanabe and Erika Suzuki and Ryoji Kojima and Yoshio Suzuki and Harumi Okuyama",

year = "1990",

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T1 - Effect of dietary α-linolenate/linoleate balance on crescent type-anti-glomerular basement membrane nephritis in rats

AU - Watanabe, Shiro

AU - Suzuki, Erika

AU - Kojima, Ryoji

AU - Suzuki, Yoshio

AU - Okuyama, Harumi

PY - 1990/5

Y1 - 1990/5

N2 - Rats were fed diets with three different ratios of α-linolenate (18:3 n-3) and linoleate (18:2 n-6), and then crescentic-type anti-glomerular basement membrane (GBM) nephritis was induced. The urinary protein levels and the plasma urea nitrogen levels were significantly higher, and histological abnormalities of glomeruli were seen more frequently in the high-α-linolenate group than in the high-linoleate group. The differences in dietary α-linolenate/linoleate balances were reflected in the proportions of arachidonate and eicosapentaenoate in glomerular phospholipids. Our results indicate that dietary enrichment with α-linolenate causes unfavorable effects in this anti-GBM nephritis model.

AB - Rats were fed diets with three different ratios of α-linolenate (18:3 n-3) and linoleate (18:2 n-6), and then crescentic-type anti-glomerular basement membrane (GBM) nephritis was induced. The urinary protein levels and the plasma urea nitrogen levels were significantly higher, and histological abnormalities of glomeruli were seen more frequently in the high-α-linolenate group than in the high-linoleate group. The differences in dietary α-linolenate/linoleate balances were reflected in the proportions of arachidonate and eicosapentaenoate in glomerular phospholipids. Our results indicate that dietary enrichment with α-linolenate causes unfavorable effects in this anti-GBM nephritis model.

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Effect of dietary α-linolenate/linoleate balance on crescent type-anti-glomerular basement membrane nephritis in rats

Abstract

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