Effect of dietary α-linolenate/linoleate balance on crescent type-anti-glomerular basement membrane nephritis in rats

Shiro Watanabe, Erika Suzuki, Ryoji Kojima, Yoshio Suzuki, Harumi Okuyama*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Rats were fed diets with three different ratios of α-linolenate (18:3 n-3) and linoleate (18:2 n-6), and then crescentic-type anti-glomerular basement membrane (GBM) nephritis was induced. The urinary protein levels and the plasma urea nitrogen levels were significantly higher, and histological abnormalities of glomeruli were seen more frequently in the high-α-linolenate group than in the high-linoleate group. The differences in dietary α-linolenate/linoleate balances were reflected in the proportions of arachidonate and eicosapentaenoate in glomerular phospholipids. Our results indicate that dietary enrichment with α-linolenate causes unfavorable effects in this anti-GBM nephritis model.

Original languageEnglish
Pages (from-to)267-272
Number of pages6
JournalLipids
Volume25
Issue number5
DOIs
StatePublished - 1990/05

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Cell Biology

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