Discovery of hyaluronidase inhibitors from natural products and their mechanistic characterization under DMSO-perturbed assay conditions

Keyphrases

• Natural Products 100%
• Catechin 100%
• Hyaluronidase Inhibitor 100%
• Assay Conditions 100%
• Mechanistic Characterization 100%
• Frequent Hitters 66%
• Inhibitory Activity 33%
• Panax Japonicus 33%
• Chikusetsusaponin 33%
• Binding Site 33%
• Catalytic Site 33%
• Hyaluronan 33%
• Non-specific Binding 33%
• Moderate Activity 33%
• Drug Discovery 33%
• Degradative Enzymes 33%
• Biological Assay 33%
• Epicatechin 33%
• Prunus Salicina 33%
• Binding Inhibitor 33%
• Robust Methodology 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Natural Product 100%
• Catechin 100%
• Hyaluronidase 100%
• Dimethyl Sulfoxide 100%
• Binding Site 33%
• Hyaluronic Acid 33%
• Drug Discovery 33%
• Epicatechin 33%
• Bioassay 33%
• Chikusetsu Saponin 33%
• Panax japonicus 33%
• Prunus 33%

Biochemistry, Genetics and Molecular Biology

• Catechin 100%
• Hyaluronidase 100%
• Enzyme 66%
• Binding Site 33%
• Restylane 33%
• Bioassay 33%
• Panax japonicus 33%
• Prunus 33%
• Epicatechin 33%