@article{1d286dadac2147f69fbaf9b31522294a,
title = "Discovery of 2-pyridineformamide thiosemicarbazones as potent antiausterity agents",
abstract = "Series of 2-pyridineformamide thiosemicarbazones were synthesized. Their preferential cytotoxicity in nutrient deprived medium (NDM) was evaluated using PANC-1 human pancreatic cancer cells by employing an antiausterity strategy. 2-Pyridineformamide thiosemicarbazones induced apoptosis and exhibited preferential cytotoxic activity toward PANC-1 cells in NDM, with potencies in the submicromolar range. These compounds are potential candidates for the development of therapeutics against pancreatic cancer.",
keywords = "2-Pyridineformamide thiosemicarbazones, Antiausterity agents, Apoptosis, Nutrition starvation, Pancreatic cancer",
author = "Bhushan Shakya and Yadav, {Paras Nath} and Ueda, {Jun Ya} and Suresh Awale",
note = "Funding Information: This work was supported by a Grant from Toyama Support Center for Young Principal Investigators in Advanced Life Sciences, Japan , and a Grant in Aid for Scientific Research (No. 24510314 ) from the Japan Society for the Promotion of Science (JSPS) to S.A., and the University Grants Commission of the Government of Nepal to B.S. We thank Dr. Rajendra Kumar Shakya, Wayne State University for the NMR data acquisition. ",
year = "2014",
month = jan,
day = "15",
doi = "10.1016/j.bmcl.2013.12.044",
language = "英語",
volume = "24",
pages = "458--461",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Ltd.",
number = "2",
}
